Kevin Matthew McKay Week 5
From OpenWetWare
Genes
- GDH1
- 2 Homo sapien Homologues:
- 1NR1 and 1L1F
- Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
- 1NR1 and 1L1F
- Expression is regulated by carbon sources
- High expression in presence of glucose and ethanol
- 2 Homo sapien Homologues:
- GDH3
- 2 Homo sapien Homologues:
- 1NR1 and 1L1F
- Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
- 1NR1 and 1L1F
- Expression regulated by carbon sources
- High expression in presence of ethanol, repressed by glucose
- 2 Homo sapien Homologues:
- GDH2
- Homo Sapien Homolog:
- GLUD2
- Deficiency causes hyperinsulinism
- GLUD2
- Expression regulated by nitrogen catabolite repression and intracellular ammonia levels
- Homo Sapien Homolog:
- GLN1
- Homo sapien homologues:
- 2OJW and 2QC8
- Changes in activity of these genes has been linked to Alzheimer's disease
- Expression regulated by nitrogen source and amino acid limitation
- GLT1
- No Homo sapien homolog
- Expression regulated by glutamate-mediated repression and GLN3P/GCN4P-mediated activation, availability of nitrogen and glutamate, and when amino acids are limiting, GLT1 expression is activated by GCN4P.
- L-GLutamate is involved in 56 pathways