User:Johnsy/Lipoprotein Modelling: Difference between revisions
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*Understand the pathways for maintaining cholesterol homeostasis in the human body and various diseased states resulting in a level of blood cholesterol away from homeostasis. | *Understand the pathways for maintaining cholesterol homeostasis in the human body and various diseased states resulting in a level of blood cholesterol away from homeostasis. | ||
*Develop an understanding of how lipoproteins are transported into and out of the cells in the human body, especially hepatocytes. | *Develop an understanding of how lipoproteins are transported into and out of the cells in the human body, especially hepatocytes. | ||
*Reserach and understand current models of lipoprotein metabolism. | *Reserach and understand current models of lipoprotein transport and metabolism. | ||
*Adapt and develop the current models of lipoprotein metabolism to more reflect the biochemistry of the process. | *Adapt and develop the current models of lipoprotein metabolism to more accurately reflect the biochemistry of the process. | ||
*Adapt and develop the current models to fit specific cell types, such as hepatocytes, and account for the variation in function of those different cell types. | |||
*Understand the mechanism by which statins affect HMG-CoA reductase and test input parameters of the mathematical models developed to account for its actions. | |||
*Understand the importance of lipoproteins, especially LDL, to the generation of atherosclerosis. | *Understand the importance of lipoproteins, especially LDL, to the generation of atherosclerosis. | ||
*Test the model with various physiological parameters in an attempt to better understand the effects of diseases such as familial hypercholesterolemia (FH) | *Test the model with various physiological parameters in an attempt to better understand the effects of diseases such as familial hypercholesterolemia (FH) | ||
Revision as of 20:02, 10 October 2007
Modelling Lipoprotein Metabolism
BEng Final Year Individual Project 2007/2008
John Sy
Supervisor: Mauricio Barahona, PhD
Aims
- Understand the mechanism by which cholesterol is produced in cells (cholesterol biosynthesis) beginning from Acetyl-CoA and which enzymes limit the rate at which cholesterol and its derivatives are produced.
- Understand the pathways for maintaining cholesterol homeostasis in the human body and various diseased states resulting in a level of blood cholesterol away from homeostasis.
- Develop an understanding of how lipoproteins are transported into and out of the cells in the human body, especially hepatocytes.
- Reserach and understand current models of lipoprotein transport and metabolism.
- Adapt and develop the current models of lipoprotein metabolism to more accurately reflect the biochemistry of the process.
- Adapt and develop the current models to fit specific cell types, such as hepatocytes, and account for the variation in function of those different cell types.
- Understand the mechanism by which statins affect HMG-CoA reductase and test input parameters of the mathematical models developed to account for its actions.
- Understand the importance of lipoproteins, especially LDL, to the generation of atherosclerosis.
- Test the model with various physiological parameters in an attempt to better understand the effects of diseases such as familial hypercholesterolemia (FH)
