Qianben Wang Laboratory: Difference between revisions

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[[Image:Myles with Qianben's group 700pixel.jpg]]
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<center><font face="lucida fax" style= "color:Yellow" size="+10">'''Qianben Wang Laboratory'''</font>
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[[Wang | <font face="trebuchet ms" style="color:#ffffff"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<center><font face="lucida fax" style= "color:Yellow" size="+2">'''Laboratory of Cancer Epigenomics'''</font></center>
[[Wang:Research | <font face="trebuchet ms" style="color:#ffffff"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:Publications | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<center><font face="lucida fax" style= "color:Yellow" size="+1">'''Department of Cancer Biology and Genetics, The Ohio State University'''</font>
[[Wang:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Links | <font face="trebuchet ms" style="color:#ffffff"> '''Links''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Research | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Photos | <font face="trebuchet ms" style="color:#ffffff"> '''Photos''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Publications | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Lab Members | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Contact | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:News | <font face="lucida fax" style="color:#ffffff" size="+1"> '''News''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Gallery | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Gallery''' </font>]]  
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<div style="text-align:left" font face="lucia fax">'''The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.
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==Welcome to the Qianben Wang Laboratory Page==
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Revision as of 16:01, 1 July 2016

Qianben Wang Laboratory


Laboratory of Cancer Epigenomics


Department of Cancer Biology and Genetics, The Ohio State University


Home              Research              Publications              Lab Members              Contact              News              Gallery

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The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.
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