IGEM:Harvard/2006/DNA nanostructures: Difference between revisions
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==Project Overview== | ==Project Overview== | ||
*Our goal is | *Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus. | ||
*The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility. | *The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility. | ||
*As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers. | *As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers. | ||
Latest revision as of 01:15, 29 October 2006
Project Overview
- Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
- The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
- As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
- We expect that molecular containers could have several interesting scientific and clinical applications, such as
- Drug and gene delivery
- Bio-marker scavenging (early detection of biomarkers)
- Directed evolution (compartmentalized selections)
- Using multiplexing for combinatorial chemical synthesis
- Capture and stabilization of multiprotein complexes
- Protein folding (chaperones)
- Cell sorting
Working Team Members
- Tiffany Chan (talk, edits)
- Katherine Fifer (talk, edits)
- Valerie Lau (talk, edits)
- Matthew Meisel (talk, edits)
- Lewis Hahn (talk, edits)
- TA: Shawn Douglas (talk, edits)
Recent Changes
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