Biomod/2013/Todai: Difference between revisions
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<h1 class="big-title"><a name="Home"> Home</a></h1> | |||
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<h1 class="title"><a name="Oligomeric Cell Killer"> Oligomeric Cell | |||
Killer</a></h1> | |||
<p class="paragraph">Team Todai nanORFEVRE tried to make cancer-specific | |||
pore-forming DNA origami drug.</p> | |||
<p class="paragraph">We named this DNA nanostructure "Oligomeric Cell | |||
Killer".</p> | |||
</article> | |||
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<article> | |||
<h1 class="title"><a name="Abstract"> Abstract</a></h1> | |||
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<center><iframe width="480" height="360" src="//www.youtube.com/embed/E4RaZ41hJ7w" frameborder="0" allowfullscreen></iframe> | |||
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<img src="http://openwetware.org/images/4/46/Todai_home.png" width="450px" | |||
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<p class="paragraph"> | |||
Cancer is one of the most common diseases in the world. Chemotherapy is a | |||
popular treatment for cancer, however, it attacks normal cells in addition to | |||
cancer cells, causing severe side effects in some cases. Recently drug | |||
delivery system (DDS) has developed to improve cancer-specificity, but it is | |||
difficult to optimize delivery system for each drug. | |||
</p> | |||
<br> | |||
<p class="paragraph"> | |||
Here, we tried to make a prototype of <span style="color:#e00000">oligomeric | |||
cancer specific pore-forming DNA origami</span>, termed <span | |||
style="color:#e00000"><b>Oligomeric Cell Killer (OCK)</b></span>, which might | |||
be a side effects free anti-cancer drug. | |||
</p> | |||
<br> | |||
<p class="paragraph"> | |||
OCKs exist in a monomeric form in solution and penetrate into the cell | |||
randomly. Cancer specific molecules on the membrane of cancer cell trigger | |||
the oligomerization of OCK, resulting in the pore-forming and <span | |||
style="color:#e00000">subsequent death of cancer cell</span>. In contrast, | |||
the OCKs keep monomeric form in the normal cell, allowing <span | |||
style="color:#e00000">the normal cell to keep alive</span>. | |||
Our study might be the basis for cancer specific drug. | |||
</p> | |||
<br> | |||
<!--To Project--> | |||
<div class="to-project"> | |||
<a href="http://openwetware.org/wiki/Biomod/2013/Todai/Project"> | |||
＞＞To Project＜＜ | |||
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<footer style="position:relative;left:400px"> | |||
<small> | |||
Copyright © Todai nanORFEVRE, all rights reserved. | |||
</small> | |||
</footer> | |||
</body> | |||
</html> | |||
Latest revision as of 00:45, 27 October 2013
<html> <head> <meta name="viewport" content="width=1200">
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<figure>
<img src="http://openwetware.org/images/9/9c/Logo-OCKver.png" width=730px height=128px>
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<img src="http://openwetware.org/images/b/b1/Return-top-0828new.png" width:60px height:60px>
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</body> </html>
<html> <head> <style> .to-project a{
font-size:130%; position:relative; left:500px; }
</style> </head>
<body>
<a name="Home"> Home</a>
<article>
<a name="Oligomeric Cell Killer"> Oligomeric Cell Killer</a>
Team Todai nanORFEVRE tried to make cancer-specific pore-forming DNA origami drug.
We named this DNA nanostructure "Oligomeric Cell Killer".
</article>
<article>
<a name="Abstract"> Abstract</a>
<figure> <img src="http://openwetware.org/images/4/46/Todai_home.png" width="450px"
height="350px" >
</figure>
Cancer is one of the most common diseases in the world. Chemotherapy is a popular treatment for cancer, however, it attacks normal cells in addition to cancer cells, causing severe side effects in some cases. Recently drug delivery system (DDS) has developed to improve cancer-specificity, but it is difficult to optimize delivery system for each drug.
Here, we tried to make a prototype of oligomeric cancer specific pore-forming DNA origami, termed Oligomeric Cell Killer (OCK), which might be a side effects free anti-cancer drug.
OCKs exist in a monomeric form in solution and penetrate into the cell randomly. Cancer specific molecules on the membrane of cancer cell trigger the oligomerization of OCK, resulting in the pore-forming and subsequent death of cancer cell. In contrast, the OCKs keep monomeric form in the normal cell, allowing the normal cell to keep alive. Our study might be the basis for cancer specific drug.
<a href="http://openwetware.org/wiki/Biomod/2013/Todai/Project"> ＞＞To Project＜＜
</a>
</article>
<footer style="position:relative;left:400px"> Copyright © Todai nanORFEVRE, all rights reserved. </footer> </body> </html>
