Brown BIOL1220:Notebook/SynBio in Theory and Practice/Genes/ADAR: Difference between revisions
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Elias Scheer (talk | contribs) New page: == '''Adenosine Deaminases that act on RNA (ADARs)''' == === The Functions of the ADAR Family === * Three members of this deaminase family are known: ADAR 1, ADAR 2, and ADAR 3 that share... |
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* In mice, the editosomes with ADAR proteins require some cis-acting elements like an intronic 'editing-site complementary sequence (ECS)'. Although evolutionarily conserved, the actual role of ECS is not yet elucidated in humans. ''A representation of the editing complex is shown below.'' | * In mice, the editosomes with ADAR proteins require some cis-acting elements like an intronic 'editing-site complementary sequence (ECS)'. Although evolutionarily conserved, the actual role of ECS is not yet elucidated in humans. ''A representation of the editing complex is shown below.'' | ||
[[Image:ADAR_editosome.png]] | [[Image:ADAR_editosome.png]] | ||
*The deamination of adenosines (A) to inosine (I) is the most common editing event. | |||
=== Why edit pre-mRNA? === | |||
* Increase genetic diversity through changes in the transcriptome. For an example of this, see [[ADAR Functions in Receptors|below]]. | |||
Revision as of 04:41, 23 February 2009
Adenosine Deaminases that act on RNA (ADARs)
The Functions of the ADAR Family
- Three members of this deaminase family are known: ADAR 1, ADAR 2, and ADAR 3 that share a common modular domain structure.
- ADARs modify pre-mRNA and recognize structural determinants in the RNA.
- In mice, the editosomes with ADAR proteins require some cis-acting elements like an intronic 'editing-site complementary sequence (ECS)'. Although evolutionarily conserved, the actual role of ECS is not yet elucidated in humans. A representation of the editing complex is shown below.
- The deamination of adenosines (A) to inosine (I) is the most common editing event.
Why edit pre-mRNA?
- Increase genetic diversity through changes in the transcriptome. For an example of this, see below.
