Rm1, RASSL Based on hMC4-Receptor

Rm1:

This is the RASSL Melanocortin No. 1. The sequence is identical to hMC4R except for the L106P substitution that renders it a Gs-coupled RASSL. Rm1 has a lower basal activity than the wild-type receptor by ~ 30%.

gacggatcgggagatctcccgatcccctatggtcgactctcagtacaatctgctctgatgcc gcatagttaagccagtatctgctccctgcttgtgtgttggaggtcgctgagtagtgcgcgag caaaatttaagctacaacaaggcaaggcttgaccgacaattgcatgaagaatctgcttaggg ttaggcgttttgcgctgcttcgcgatgtacgggccagatatacgcgttgacattgattattg actagttattaatagtaatcaattacggggtcattagttcatagcccatatatggagttccg cgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattga cgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgg gtggactatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtac gccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgacct tatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatg cggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtct ccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaat gtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctat ataagcagagctctctggctaactagagaacccactgcttactggcttatcgaaattaatac gactcactatagggagacccaagctggctagttaagcttggtaccgagctcggatccactag tccagtgtggtggaattgcccttatcaattcagggggacactggaattcgcccttgcctatc tagaataaacgctcaactttggcagatccacc