Stephanopoulos:Projects: Difference between revisions
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* the modification of biochemical pathways inside cells and | * the modification of biochemical pathways inside cells and | ||
* the rigorous evaluation of the resulting cellular phenotypes. | * the rigorous evaluation of the resulting cellular phenotypes. | ||
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Our most recent research has been focused on the following topics: | Our most recent research has been focused on the following topics: | ||
* Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals | * [[Stephanopoulos Lab:Production of biochemicals in E. coli | '''Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals''']] | ||
* Inverse Metabolic Engineering | * [[Stephanopoulos Lab:Inverse Metabolic Engineering | '''Inverse Metabolic Engineering''']] | ||
* gTME | * [[Stephanopoulos Lab:gTME | '''gTME''']] | ||
* Flux Determination | * [[Stephanopoulos Lab:Flux Determination | '''Flux Determination''']] | ||
* Hepatocyte Physiology | * [[Stephanopoulos Lab:Hepatocyte Physiology | '''Hepatocyte Physiology''']] | ||
* Metabolomics | * [[Stephanopoulos Lab:Metabolomics | '''Metabolomics''']] | ||
* Systems Biology | * [[Stephanopoulos Lab:Systems Biology | '''Systems Biology''']] | ||
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Revision as of 23:04, 12 July 2006
Research
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Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
- the modification of biochemical pathways inside cells and
- the rigorous evaluation of the resulting cellular phenotypes.
Our most recent research has been focused on the following topics:
<html>To accomplish the above goals we make use of a diverse array of scientific tools and methods, many of which have also become areas of research for our group:
- <a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a> - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
- <a href="Fluxes.shtml">Methods for intracellular flux determination</a> - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.
- <a href="Microarray.shtml">DNA microarrays</a> - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
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<a href="BioReactor.shtml">Bioreaction network analysis.</a>
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