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Revision as of 13:58, 30 August 2013
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<a name="Oligomeric Cell Killer"> Oligomeric Cell Killer</a>
Team Todai nanORFEVRE tried to make cancer-specific pore-forming DNA origami drug.
We named this DNA nanostructure "Oligomeric Cell Killer".
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Cancer is one of the most malignant diseases, which accounts for about 13 percent of deaths in the world. One of the most effective medical treatments for it is chemotherapy, but it often attacks not only cancer cells but also normal cells, leading severe side effects. Recently the drug delivery system has been developed to improve cancer-specificity, but it isn't easy to customize delivery system one by one corresponding to each drug.
Here we propose an anti-cancer drug which doesn’t need delivery system for cancer specificity: cancer-specific pore-forming DNA origami drug. Inspired by a toxin produced by an animal and a mechanism existing in the human immune system, we designed DNA origami subunits which coordinately kill a cell. The process of killing is as follows. Subunits stick in the cell membrane with cholesterol site. Then they oligomerize so that they form pore on the membrane. This pore disrupts the phospholipid bilayer of cells, leading cell lysis and death. Since we use DNA origami, it is expected that we can combine with it pre-existing DNA computing circuit and improve cancer-specificity.
Our general idea can be divided into two steps, cancer-recognition and killing. DNA computing circuit for recognition has already existed, so we set the goal of the biomod 2013 the development of pore-forming DNA origami for the killing system.
In Japan meeting for biomod2013, we will report the interaction between DNA nanostructures and cell membrane and several methods for oligomerizing.
<a href="http://openwetware.org/wiki/Biomod/2013/Todai/Project"> ＞＞To Project＜＜ </a>
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