User:Tkadm30/Notebook/chim trills notebook/Research

Research topics

Translocation and internalization of metal oxide nanoparticles (PM2.5)

• Aluminium-induced neurotoxicity and chronic neuroinflammation in the microglia
• Translocation of PM2.5 to the brain.
• The Effects of Nanomaterials as Endocrine Disruptors.

Translocation of aluminium oxide nanoparticles in the microglia

• Glia activation induced by peripheral administration of aluminum oxide nanoparticles in rat brains

Nanotoxicity and genotoxicity of drug nanoparticles exposure

• The immunological nanotoxicity and genotoxicity of fine particulate matter (PM2.5) is under investigation.
• The chemical clumping behavior of PM2.5 nanoparticles may require a ultrasonic atomization delivery system.
• The synthetic nature of PM2.5 require further research.

Characterization of the Gulf War Syndrome/X variant

The phenotype of the Gulf War Syndrome/X variant (GWSX) is not well characterized. The immunotoxicity and nanotoxicity of PM2.5 nanoparticles require further research.

Epidemiological evidences of PM2.5-mediated damage to neuroimmune system:

• Alteration of cytokines production
• Neuroinflammation
• Mitochondrial DNA (mtDNA) oxidative stress (Aluminium oxide?)
• Microglial activation markers? (MAC1, Glutaminase, TLR-2)
• Decrease in neurotrophin expression
• Modulation of neuroendocrine response

Nanotoxicity of metal oxides nanoparticles:

• Aluminium oxide nanoparticles may induce proinflammatory response and oxidative stress.

Further readings:

• The neuroendocrinology of chronic fatigue syndrome.
• Aluminium oxide nanoparticles induce mitochondrial-mediated oxidative stress and alter the expression of antioxidant enzymes in human mesenchymal stem cells.

Nanoparticle-based drug delivery

Translocation and internalization of NPs:

• Synthetic nucleic acid delivery systems
• Engineered nanoparticles can be developed to enter blood-brain barrier through intracellular (siRNA) delivery.
• Cellular internalization of quantum dots.

Aerosolized drug nanoparticles

• Photoactivated drug delivery vectors
• Monodisperse aerosols

Research projects

Differential effects of drug nanoparticles on the neuroimmune system and microglial cells

I aim to understand the nanotoxicity and genotoxicity of long-term PM2.5 exposure on physiological and neurological processes:

• In summary, I'm interested to understand the effects of nanoparticles on chronic pulmonary diseases (COPD), DNA/RNA and NADPH dysregulation.
• The differential effects of drug nanoparticles on chronic neuroinflammation and microglial activation (reactive microgliosis) require further research.

Keywords: metal oxides, nanoparticles, bioaerosol, drug delivery, CNS, neuroinflammation, microglia, PM2.5

Knowledge is power: Psychology of modern psychochemical warfare.

Clandestine geoengineering activity is a controversial issue. The aim of this research project is to understand how artificial intelligence is used to deter scientific research on PM2.5.

Keywords: psychology, consciousness, psychochemicals, science, deception, media blackout, cognitive dissonance, disinformation, cognitive infiltration, education, research, PM2.5

See also

• Photographic evidences