Stephanopoulos:Projects
<html>
<align=left>
Research
</align>
</html>
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components: a) the modification of biochemical pathways inside cells and b) the rigorous evaluation of the resulting cellular phenotypes.
<html>
Our most recent research has been focussed on the following topics:
- <a href="Biochemicals.shtml">Metabolic Engineering of E.Coli for the production of biochemicals.</a>
- <a href="Inverse.shtml">Inverse Metabolic Engineering</a>
- <a href="gTME.shtml">gTME</a>
- <a href="Flux.shtml">Flux Determination</a>
- <a href="Hepatocyte.shtml">Hepatocyte Physiology</a>
- <a href="Metabolomics.shtml">Metabolomics</a>
- <a href="SysBio.shtml">Systems Biology</a>
To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
- <a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a> - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
- <a href="Fluxes.shtml">Methods for intracellular flux determination</a> - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.
- <a href="Microarray.shtml">DNA microarrays</a> - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
-
<a href="BioReactor.shtml">Bioreaction network analysis.</a>
</body>
</html>
<html>
</html>
<html>
Address
Massachusetts Institute of Technology
Department of Chemical Engineering
Cambridge, MA 02139
Room 56-469<a href="http://www.mit.edu">MIT</a> | <a href="/wiki/Stephanopoulos_Lab">HOME</a>
Last Modified:
Monday, July 10th, 2006 - by <a href="Adrian.shtml">afi</a>.
gnswebpage-www@mit.eduTelephones
office | 617.258.0398
lab | 617.253.6591
lab | 617.258.0349
lab | 617.253.6521
fax | 617.253.3122
</html>
