Stephanopoulos:Projects
Research
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Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components: a) the modification of biochemical pathways inside cells and b) the rigorous evaluation of the resulting cellular phenotypes.
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Our most recent research has been focussed on the following topics:
- <a href="Biochemicals.shtml">Metabolic Engineering of E.Coli for the production of biochemicals.</a>
- <a href="Inverse.shtml">Inverse Metabolic Engineering</a>
- <a href="gTME.shtml">gTME</a>
- <a href="Flux.shtml">Flux Determination</a>
- <a href="Hepatocyte.shtml">Hepatocyte Physiology</a>
- <a href="Metabolomics.shtml">Metabolomics</a>
- <a href="SysBio.shtml">Systems Biology</a>
To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
- <a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a> - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
- <a href="Fluxes.shtml">Methods for intracellular flux determination</a> - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.
- <a href="Microarray.shtml">DNA microarrays</a> - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
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<a href="BioReactor.shtml">Bioreaction network analysis.</a>
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