Koop:Mdwilson

Michael Wilson, PhD Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Robinson Way, Cambridge, CB2 0RE phone:01223404502 email: michael.wilson ^at^ cancer ^dot^ org ^uk^

I am a Postdoctoral Research fellow in Duncan Odom's laboratory at the Cambridge Research Insitute

My PhD was done in the Koop lab in the Centre for Biomedical Research at University of Victoria.

Research Interests

Comparative genomics and evolution

• • Evolution of transcription factor binding
  • Genomics regions associated with duplications, insertions, deletions and disease
  • 7q11 William-Beuren syndrome
  • 7q22 Acute myeloid leukemia
  • Paired immunoglobulin like receptors
  • Segmental duplications
  • Alternative splicing

Using mouse genetics and embryonic stem cells to investigate the function of novel genes

• • Zonadhesin -- Zonadhesin is a novel gene that is under positive selection and is hypothesized to play a role in the species specific recognition of sperm and egg in mammals (In collaboration with Daniel Hardy and Andras Nagy)
  • Ars2 -- Ars2 was first discovered by others as a gene that conferred arsenite resistance to an arsenite sensitive cell line. We characterized this gene in humans and mice and are currently studying the phenotype of Ars2 mutants. This is in collaboration with Andras Nagy, Perry Howard, Robert Burke and Diana Wang.
  • Gnrhr -- This is a collaboration with Dr. Nancy Sherwood and Sheng Wu.
  • Achi -- A novel gene embedded in Ache (In collaboration with Corrinne Lobe, more information coming soon).

Education

PhD, University of Victoria, October 2005

B.Sc., University of Victoria. My undergraduate degree was in Biochemistry and Hispanic studies.

Publications

Wilson MD, Cheung J, Martindale DW, Scherer SW, and Koop BF. Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. Physiol Genomics. 2006 Nov 27;27(3):201-18. DOI:10.1152/physiolgenomics.00284.2005 | Hunt PN, Wilson MD, von Schalburg KR, Davidson WS, and Koop BF. Expression and genomic organization of zonadhesin-like genes in three species of fish give insight into the evolutionary history of a mosaic protein. BMC Genomics. 2005 Nov 22;6:165. DOI:10.1186/1471-2164-6-165 | Cheung J, Wilson MD, Zhang J, Khaja R, MacDonald JR, Heng HH, Koop BF, and Scherer SW. Recent segmental and gene duplications in the mouse genome. Genome Biol. 2003;4(8):R47. DOI:10.1186/gb-2003-4-8-r47 | Montpetit A, Wilson MD, Chevrette M, Koop BF, and Sinnett D. Analysis of the conservation of synteny between Fugu and human chromosome 12. BMC Genomics. 2003 Jul 23;4(1):30. DOI:10.1186/1471-2164-4-30 | Wen XY, Hegele RA, Wang J, Wang DY, Cheung J, Wilson M, Yahyapour M, Bai Y, Zhuang L, Skaug J, Young TK, Connelly PW, Koop BF, Tsui LC, and Stewart AK. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Hum Mol Genet. 2003 May 15;12(10):1131-43. DOI:10.1093/hmg/ddg124 | Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, and Tsui LC. Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. DOI:10.1126/science.1083423 | Shuttleworth TL, Wilson MD, Wicklow BA, Wilkins JA, and Triggs-Raine BL. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. J Biol Chem. 2002 Jun 21;277(25):23008-18. DOI:10.1074/jbc.M108991200 | Wilson MD, Ruttan CC, Koop BF, and Glickman BW. ERCC1: a comparative genomic perspective. Environ Mol Mutagen. 2001;38(2-3):209-15. DOI:10.1002/em.1073 | Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W, and Koop BF. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res. 2001 Mar 15;29(6):1352-65. DOI:10.1093/nar/29.6.1352 | Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, and Koop BF. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome. 2000 Oct;11(10):890-8. DOI:10.1007/s003350010166 | Brown G, Martindale D, Wilson MD, Koop BF. Mouse and human DNA sequence comparisons: further evidence for a mosaic model of genomic evolution. In Sankoff D, Nadeau JH, eds. Comparative Genomics: Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families. Volume 1 of Series in Computational Biology. Dordrecht, NL: Kluwer Academic Press; 2000.