Registry of Standard Biological Models/Basic Component Models/Activated Promoter

ID: Activated Promoter

• Description: Promoter activated by an activator molecule
• Hypothesis:
  • Simple binding of the activator on the promoter (monod-type equation)
  • Continuous transcription rate with an existing maximum rate of transcription
  • Transcription rate depends on number of gene copies
• Inputs:
  • nb-gene-copies
  • activator
• Outputs:
  • PoPs
• Internal parameters:
  • max-transcription-rate (per gene copy)
  • sensitivity

CellML structure (CellML 1.1 spec)

• Component: ActivatedPromoter
• Units:
  • TBD
• Variables:
  • nbGeneCopies (public interface = in / init value = 1.0)
  • maxTranscriptionRate (public interface = none / init value = XXX)
  • sensitivity (public interface = none / init value = XXX)
  • activator (public interface = in )
  • PoPsOUT (public interface = out / init value = 0.)
• MathML
  • <amsmath>PoPsOUT = \frac{maxTranscriptionRate*nbGenesCopies*activator}{sensitivity + activator}</amsmath>