Registry of Standard Biological Models/Basic Component Models/Activated Promoter

Activated Promoter Architecture

Description: Promoter activated by an activator molecule Hypothesis: Binding of the activator on the promoter (Hill-function-type equation) Continuous transcription rate with an existing maximum rate of transcription Transcription rate depends on number of gene copies Inputs: activator nb-gene-copies Outputs: PoPs_OUT Internal parameters: max-transcription-rate-per-gene dissociation-constant Hill-coefficient

Activated Promoter Brick Architecture

CellML structure (CellML 1.1 spec)

• Component: ActivatedPromoter
• Units:
  • TBD
• Variables:
  • nbGeneCopies (public interface = in / init value = 1.0)
  • maxTranscriptionRate (public interface = none / init value = XXX)
  • sensitivity (public interface = none / init value = XXX)
  • activator (public interface = in )
  • PoPsOUT (public interface = out / init value = 0.)
• MathML
  • <amsmath>PoPsOUT = \frac{maxTranscriptionRate*nbGenesCopies*activator}{sensitivity + activator}</amsmath>