20.109(F08):EL-KW Module3: Difference between revisions

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====The Problem of Drug-Resistant Staff====
====The Problem of Drug-Resistant Staff====


Methicillin-Resistant ''Staphylococcus aureus'', or MRSA, is form of ''Staphylococcus aureus''.  Infection with MRSA can cause painful skin and soft tissue conditions and, if untreated blood infections or bacterial pneumonia.  Hospital-acquired MRSA (HA-MRSA) is increasingly common due to lack of following sterile procedures, the great number of open wounds/medical procedures, and a higher number of immuno-compromised patients.[http://www3.niaid.nih.gov/topics/antimicrobialResistance/Examples/mrsa/overview.htm]  Approximately 31.8 MRSA infections per 100,000 people were estimated to have occurred in 2005, translating to 94,360 total infections. 86% of these were hostpial-acquired.[http://jama.ama-assn.org/cgi/content/full/298/15/1763]


====Biological Sensors====
====Biological Sensors====

Revision as of 16:10, 18 November 2008

Kerry and Elizabeth's Research Proposal

Topic Description

The Problem of Drug-Resistant Staff

Methicillin-Resistant Staphylococcus aureus, or MRSA, is form of Staphylococcus aureus. Infection with MRSA can cause painful skin and soft tissue conditions and, if untreated blood infections or bacterial pneumonia. Hospital-acquired MRSA (HA-MRSA) is increasingly common due to lack of following sterile procedures, the great number of open wounds/medical procedures, and a higher number of immuno-compromised patients.[1] Approximately 31.8 MRSA infections per 100,000 people were estimated to have occurred in 2005, translating to 94,360 total infections. 86% of these were hostpial-acquired.[2]

Biological Sensors

Electronic Sensing of Staff Binding

Background Articles

Biosensor Background Articles

Fluorescent Proteins as Biomarkers and Biosensors

Biomolecule immobilization in biosensor development: tailored strategies based on affinity interactions. <--- restricted access

Reagentless optical biosensors for organic compounds based on auto-indicating proteins.

Protein Engineering and Electrochemical Biosensors, Book Chapter

Protein hinges for bioelectronics

Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins (described in above article)

Biosensor technology: Technology push versus market pull

What are biosensors?

Fibronectin Binding

Fibronectin binding to Integrin(Elasticity of Fn type3)

Dynamics of the interaction between a fibronectin molecule and a living bacterium under mechanical force

Fibronectin binding to Staphylococcus aureus

Hinge bending within the cytokine receptor superfamily revealed by the 2.4 A crystal structure of the extracellular domain of rabbit tissue factor

Bioelectronics and Hinge Bending

Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins