20.109(F10):Variable Genetic Timer: Difference between revisions
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===Synthetic Systems=== | ===Synthetic Systems=== | ||
====RTC Counter==== | |||
Riboregulated transcriptional cascade. A step loop structure blocks the RBS and prevents transcription. Pulses of Arabinose inhibit this loop and allow the next stage in the cascade to begin. | |||
'''Ref:''' [http://www.sciencemag.org/citmgr?gca=sci;324/5931/1199 Synthetic Gene Networks That Count]. Ari E. Friedland, Timothy K. Lu, Xiao Wang, David Shi, George Church, and James J. Collins. Science 29 May 2009: 324 (5931), 1199-1202. | |||
=Research Problems and Goals= | =Research Problems and Goals= | ||
Revision as of 10:12, 23 November 2010
The goal of a variable genetic timer is to drive a time-delayed transcriptional response to a given input, where the delay is gain is proportional to a particular chemical input.
Background Information
Similar Systems
Natural Systems
Lots of natural timers include both natural cell division regulation
- A cell-intrinsic timer that operates during oligodendrocyte development. Béatrice Durand, Martin Raff
Synthetic Systems
RTC Counter
Riboregulated transcriptional cascade. A step loop structure blocks the RBS and prevents transcription. Pulses of Arabinose inhibit this loop and allow the next stage in the cascade to begin.
Ref: Synthetic Gene Networks That Count. Ari E. Friedland, Timothy K. Lu, Xiao Wang, David Shi, George Church, and James J. Collins. Science 29 May 2009: 324 (5931), 1199-1202.
