20.109(F11): Cara Brown & Emily Brown: Difference between revisions
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Stem cells and infectious diseases | Stem cells and infectious diseases | ||
===Research | ===Research Ideas=== | ||
How can stem cells better aid in the process of fighting/curing an infectious disease. | How can stem cells better aid in the process of fighting/curing an infectious disease. | ||
~creating patient specific stem cells in vitro for stem cell therapy | ~creating patient specific stem cells in vitro for stem cell therapy | ||
~taking research from stem cell therapy (HIV cured in patient by total stem cell replacement) to develop strong therapeutics | |||
~~knockout of CCR5 in HIV using RNAi, etc | |||
~~knockout of gene to treat or prevent malaria (Duffy antigen?) | |||
Engineering human blood vessel cells to express EPO under the control of light | |||
Using vampire bacterial predators to create a living antibiotic | |||
~ Look at efficiency and lethality of using the unmutated vampire bacteria to kill other bacteria (in bacteria, in mice, in vitro human cells) | |||
~Target vampire bacteria to only destroy a certain type of bacteria | |||
~Program vampire bacteria for apoptosis after a certain length of time or in response to a particular stimuli, so you do not have to use antibiotics to destroy these living antibiotics | |||
===Resources=== | ===Resources=== | ||
Revision as of 07:40, 29 November 2011
Topic
Stem cells and infectious diseases
Research Ideas
How can stem cells better aid in the process of fighting/curing an infectious disease.
~creating patient specific stem cells in vitro for stem cell therapy ~taking research from stem cell therapy (HIV cured in patient by total stem cell replacement) to develop strong therapeutics ~~knockout of CCR5 in HIV using RNAi, etc ~~knockout of gene to treat or prevent malaria (Duffy antigen?)
Engineering human blood vessel cells to express EPO under the control of light
Using vampire bacterial predators to create a living antibiotic ~ Look at efficiency and lethality of using the unmutated vampire bacteria to kill other bacteria (in bacteria, in mice, in vitro human cells) ~Target vampire bacteria to only destroy a certain type of bacteria ~Program vampire bacteria for apoptosis after a certain length of time or in response to a particular stimuli, so you do not have to use antibiotics to destroy these living antibiotics
Resources
Klessing, Ann A. "Curing HIV Disease with Stem Cell Therapy". Bedford Stem Cell Research Foundation, June 2010. Date accessed: 25 Nov 2011. http://www.bedfordresearch.org/article/hiv-aids-stem-cell-therapy-hiv-treatment-25644
Noggle, Scott et al. "Human oocytes reprogram somatic cells to a pluripotent state". Nature, Oct 2011. http://www.nature.com/nature/journal/v478/n7367/full/nature10397.html
Suga, Hidetaka et al. "Self-formation of functional adenohypophysis in three-dimensional culture". Nature, Nov 2011. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10637.html#/in-vitro-functionality-as-endocrine-tissue
