20.109(S10):Notebook/T/R Blue Research Proposal/2010/04/25: Difference between revisions
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'''OVERALL GOAL''': | '''OVERALL GOAL''': | ||
We would like to find if mechanical manipulation (with exact parameter values, if we're successful) is capable of reduce natural scarring of damaged myocardial tissue so as to | We would like to find if mechanical manipulation (with exact parameter values, if we're successful) is capable of reduce natural scarring of damaged myocardial tissue so as to rescue normal function and avoid deterioration natural mechanical and electrical properties of the tissue. | ||
==Background== | ==Background== |
Revision as of 09:31, 27 April 2010
Pei and Leanna's Research Proposal | <html><img src="/images/9/94/Report.png" border="0" /></html> Main project page |
TopicTissue Engineering and Regenerative Medicine using physiologically-relevant mechanical stimuli (Tentative) Project Idea and OverviewRegeneration or repair of myocardial tissue by pulse vibrations using conditions previously shown to be conducive to skin wound healing. OVERALL GOAL: We would like to find if mechanical manipulation (with exact parameter values, if we're successful) is capable of reduce natural scarring of damaged myocardial tissue so as to rescue normal function and avoid deterioration natural mechanical and electrical properties of the tissue. BackgroundImproved success with repair and regeneration of vocal fold tissue, bone tissue, and even teeth has been accomplished through physiologically-relevant mechanical stimulation.
perform in vitro studies on cardiac tissue, combining physiologically-relevant mechanical stimuli with presence of certain growth factors that have been shown to have a positive effect on healing (minimal scarring) References
1. Palatinus JA, Rhett JM, Gourdie RG. Translational lessons from scarless healing of cutaneous wounds and regenerative repair of the myocardium. J Mol Cell Cardio. 2010;48:550-557.
2. Kutty JK, Webb K. Vibration stimulates vocal mucosa-like matrix expression by hydrogel-encapsulated fibroblasts. J Tissue Eng Regen Med. 2009;4:62-72.
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