20.20:Advanced topics
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Biological Engineering Design
Advanced topics reading schedule
Wednesdays for 1 hour during 2-5 studio block
26-152
TOPIC | DATE | Discussion leader(s) | Discussion paper(s) | Related paper(s) to enjoy |
A Voyage To Lilliput: How a small number of AA substitution change activity of a protein |
Wed Feb 6 | Natalie Kuldell and Drew Endy | Bushman FD, Ptashne M. Turning lambda Cro into a transcriptional activator |
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Natural systems have modular components | Wed Feb 13 | Ptashne “Two ‘What if” experiments”
[1] |
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You can build devices from natural modules | Wed Feb 20 | Collin’s toggle Elowitz’ repressilator |
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Natural systems are noisy | Wed Feb 27 | Hysteresis and noise | ||
Wed Mar 5 | NK and DE OoT | |||
Natural systems can be intentionally changed to be useful | Wed Mar 12 | Protein induction systems | ||
Natural systems can offer improved chassis | Wed Mar 19 | Metabolic engineering Minimal genomes Artificial cells
[4] |
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Spring Break Mar 24-28 | No class all week | |||
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Computational design of unnatural systems | Wed Apr 2 | Dwyer, Looger, Hellinga “Computational design of active enzyme” Some ex of directed evolution |
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Expanding Nature’s Genetic Programming Language | Wed Apr 9 | Chin Schultz “expanded genetic code” | ||
Programming artificial life | Wed Apr 16 | 2 genomes 1 cell 1 cell to new cell |
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Populations of cells communicate | Apr 23 | |||
Populations of cells make patterns | Wed Apr 30 | |||
Presentations 1 | Wed Apr 30 | |||
Presentations 2 | Wed May 7 | |||
Presentations 3 | Wed May 14 |