6.021/Notes/2006-11-14

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Electrodiffusion

Nernst-Planck Equation: J_n = -z_nFD_n\frac{\partial c_n}{\partial x}-u_nz_n^2F^2c_n\frac{\partial\psi}{\partial x}

Einstein's relation: Dn = unRT

Continuity: \frac{\partial J_n}{\partial x} = -z_nF\frac{\partial c_n}{\partial t}

Poisson's Equation: \frac{\partial^2 \psi}{\partial x^2} = -\frac{1}{\epsilon}\sum_n z_nFc_n(x,t)

Membranes

Jn = Gn(VmVn)

G_n = \frac{1}{\int_0^d{\frac{dx}{u_nz_n^2F^2c_n(x)}}} (electrical conductivity)

Nernst potential: V_n=\frac{RT}{z_nF}{\rm ln}\frac{c^o_n}{c^i_n} \approx \frac{60 {\rm mV}}{z_n}{\rm log}\frac{c^o_n}{c^i_n}

Cells

Gm = Gn
n

Resting membrane potential: V_m^o = \sum_n \frac{G_n}{G_m}V_n

Resting potential with active pumps: V_m^o = \sum_n \frac{G_n}{G_m}V_n - \frac{1}{G_m}\sum_n J_n^a

Core conductor model

\frac{\partial I_i(z,x)}{\partial z}=-K_m(z,t)

\frac{\partial I_o(z,x)}{\partial z}=K_m(z,t)-K_e(z,t)

\frac{\partial V_i(z,t)}{\partial z}=-r_iI_i(z,t)

\frac{\partial V_o(z,t)}{\partial z}=-r_oI_o(z,t)

THE core conductor equation: \frac{\partial^2 V_m(z,t)}{\partial z^2}=(r_o+r_i)K_m(z,t)-r_oK_e(z,t)

wave equation: \frac{\partial^2 V_m(z,t)}{\partial z^2}=\frac{1}{\nu^2}\frac{\partial^2 V_m(z,t)}{\partial t^2}

\nu = \sqrt{\frac{C}{(r_o+r_i)2\pi a}}, \nu = \sqrt{\frac{Ca}{2\rho}} \propto \sqrt{a}

v_o(z)=-\frac{r_o}{r_o+r_i}(v_m(z) - V_m^o)

Hodgkin-Huxley

G_{K}(V_m,t) = \overline{G_K} n^4(V_m,t), G_{Na}(V_m,t) = \overline{G_{Na}} m^3(V_m,t)h(V_m,t)

n(V_m,t) + \tau_n(V_m)\frac{dn(V_m,t)}{dt} = n_\infty(V_m), m(V_m,t) + \tau_m(V_m)\frac{dm(V_m,t)}{dt} = m_\infty(V_m), h(V_m,t) + \tau_h(V_m)\frac{dh(V_m,t)}{dt} = h_\infty(V_m)

x_\infty=\frac{\alpha_x}{\alpha_x+\beta_x}, \tau_x=\frac{1}{\alpha_x+\beta_x}

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