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Odelberg, SJ, Kollhoff, A, & Keating, MT (2000) Cell 103:1099-1109. | Odelberg, SJ, Kollhoff, A, & Keating, MT (2000) Cell 103:1099-1109. | ||
==Bonus Materials== | ==Bonus Materials== | ||
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Kim, DH, Villeneuve, LM, Morris, KV, & Rossi, JJ (2006) Nat Struct Mol Biol 13:793-797. | Kim, DH, Villeneuve, LM, Morris, KV, & Rossi, JJ (2006) Nat Struct Mol Biol 13:793-797. | ||
==Bonus materials== | |||
Reviews on the role of RNA in chromatin modifications | |||
'''[http://www.genesdev.org/cgi/reprint/19/14/1635?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=19&firstpage=1635&resourcetype=HWCIT RNA meets chromatin]''' | |||
'''[http://www.nature.com/nature/journal/v431/n7006/pdf/nature02875.pdf RNAi and heterochromatin]''' | |||
Revision as of 23:11, 15 November 2006
Week 1: Introduction
Week 2: Chromatin Functions to Define Cell State
Papers
Chromosomal Subunits in Active Genes Have an Altered Conformation
Weintraub, H & Groudine, M. (1976) Science 193, 848-856.
Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Meshorer, E, Yellajoshula, D, George, E, Scambler, PJ, Brown, DT, & Misteli, T. (2006) Dev Cell 10, 105-116.
Bonus Materials
Commentary on Meshorer et al paper
Supplemental Data for Meshorer et al paper
Obituary for Harold Weintraub from Molecular Biology of the Cell, 1995 (by Marc Kirschner)
Obituary for Harold Weintraub from Cell, 1995 (by Richard Axel & Tom Maniatis)
Week 3: Chromatin Structure and Discovery of Chromatin Modifying Enzymes
Papers
Brownell, J. E., Zhou, J., Ranalli, T., Kobayashi, R., Edmondson, D. G., Roth, S. Y., and Allis, C. D. (1996). Cell 84, 843-851.
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
Taunton, J., Hassig, C. A., and Schreiber, S. L. (1996). Science 272, 408-411.
Bonus Materials
Obituary of Alan Wolffe: Champion of Chromatin
Week 4: Methylation and the Emergence of the "Histone Code"
Papers
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001). Nature 410, 116-120.
Wysocka, J., Swigut, T., Milne, T. A., Dou, Y., Zhang, X., Burlingame, A. L., Roeder, R. G., Brivanlou, A. H., and Allis, C. D. (2005). Cell 121, 859-872.
Bonus Materials
Histone Code and Chromatin Cross-Talk
Week 5: Heritable Gene Expression
Papers
Rb targets histone H3 methylation and HP1 to promoters.
Nielsen, S. J., Schneider, R., Bauer, U. M., Bannister, A. J., Morrison, A., O'Carroll, D., Firestein, R., Cleary, M., Jenuwein, T., Herrera, R. E., and Kouzarides, T. (2001). Nature 412, 561-565
Ayyanathan, K., Lechner, M. S., Bell, P., Maul, G. G., Schultz, D. C., Yamada, Y., Tanaka, K., Torigoe, K., and Rauscher, F. J., 3rd (2003). Genes Dev 17, 1855-1869.
Bonus Materials
Commentary on the Human Epigenome Project
Commentary on Kouzarides Paper
Week 6: Pluripotency Regulators & Stem Cell Differentiation
Papers
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
Chambers, I, Colby, D, Robertson, M, Nichols, J, Lee, S, Tweedle, S, & Smith, A. (2003). Cell 113, 643-655.
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H, Lieberam, I, Porter, JA, & Jessell, TM. (2002). Cell 110, 385-397.
Bonus Materials
Commentary on Chambers et al paper
Perspective on potential uses for ES cells and issues they raise
NIH report on prospects for neural regeneration using stem cells
Week 7: Regulation of Early Development by Polycomb Proteins
Papers
Role of histone H3 lysine 27 methylation in Polycomb-group silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., and Zhang, Y. (2002). Science 298, 1039-1043.
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., and Helin, K. (2006). Genes Dev 20, 1123-1136.
Bonus Materials
News article on how polycomb proteins regulate cell fate
Review of Polycomb, Stem Cells and Cancer
Week 8: Master Regulators of Differentiation: The story of MyoD
Papers
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, RL, Weintraub, H, & Lassar, AB (1987). Cell 51:987-1000.
An initial blueprint for myogenic differentiation
Blais, A, Tsikitis, M, Acosta-Alvear, D, Sharan, R, Kluger, Y, & Dynlacht, BD (2005), Genes Dev 19:553-569.
Bonus Materials
Recent review on MyoD and how it functions as a 'master switch' in development
Week 9: Transdifferentiation, Dedifferentiation, and the Adoption of Alternate Cell Fates
Papers
K Takahashi & S Yamanaka (2006) Cell 126:663-676.
Dedifferentiation of mammalian myotubes induced by msx1
Odelberg, SJ, Kollhoff, A, & Keating, MT (2000) Cell 103:1099-1109.
Bonus Materials
Commentary on Takahashi & Yamanaka paper
Supplemental Materials for Takahashi & Yamanaka paper
Review on nuclear reprogramming and pluripotency
Review on muscle regeneration and dedifferentiation
Week 10: The RNAi machinery and chromatin
Papers
Small interfering RNA-induced transcriptional gene silencing in human cells
Morris, KV, Chan, SW-L, Jacobsen, SE, & Looney, DJ (2004) Science 305:1289-1292.
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells
Kim, DH, Villeneuve, LM, Morris, KV, & Rossi, JJ (2006) Nat Struct Mol Biol 13:793-797.
Bonus materials
Reviews on the role of RNA in chromatin modifications
