7.342:Materials: Difference between revisions
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Chambers, I, Colby, D, Robertson, M, Nichols, J, Lee, S, Tweedle, S, & Smith, A. (2003). Cell 113, 643-655. | Chambers, I, Colby, D, Robertson, M, Nichols, J, Lee, S, Tweedle, S, & Smith, A. (2003). Cell 113, 643-655. | ||
'''[http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSN-46H7VCR-G-N&_cdi=7051&_user=501045&_orig=browse&_coverDate=08%2F09%2F2002&_sk=998899996&view=c&wchp=dGLbVzb-zSkzS&md5=f076e53b3c329b1289095a2c0dd701da&ie=/sdarticle.pdf Directed differentiation of embryonic stem cells into motor neurons.]''' | |||
Wichterle, H, Lieberam, I, Porter, JA, & Jessell, TM. (2002). Cell 110, 385-397. | |||
==Bonus Materials== | ==Bonus Materials== | ||
'''[http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSN-4CGNB11-2-3&_cdi=7051&_user=501045&_orig=browse&_coverDate=05%2F30%2F2003&_sk=998869994&view=c&wchp=dGLbVlz-zSkzS&md5=877461e8e10c22d7c030d2f55e464d8d&ie=/sdarticle.pdf Commentary on Chambers et al paper]''' | '''[http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSN-4CGNB11-2-3&_cdi=7051&_user=501045&_orig=browse&_coverDate=05%2F30%2F2003&_sk=998869994&view=c&wchp=dGLbVlz-zSkzS&md5=877461e8e10c22d7c030d2f55e464d8d&ie=/sdarticle.pdf Commentary on Chambers et al paper]''' | ||
Revision as of 17:46, 4 October 2006
Week 1: Introduction
Week 2: Chromatin Functions to Define Cell State
Papers
Chromosomal Subunits in Active Genes Have an Altered Conformation
Weintraub, H & Groudine, M. (1976) Science 193, 848-856.
Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Meshorer, E, Yellajoshula, D, George, E, Scambler, PJ, Brown, DT, & Misteli, T. (2006) Dev Cell 10, 105-116.
Bonus Materials
Commentary on Meshorer et al paper
Supplemental Data for Meshorer et al paper
Obituary for Harold Weintraub from Molecular Biology of the Cell, 1995 (by Marc Kirschner)
Obituary for Harold Weintraub from Cell, 1995 (by Richard Axel & Tom Maniatis)
Week 3: Chromatin Structure and Discovery of Chromatin Modifying Enzymes
Papers
Brownell, J. E., Zhou, J., Ranalli, T., Kobayashi, R., Edmondson, D. G., Roth, S. Y., and Allis, C. D. (1996). Cell 84, 843-851.
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
Taunton, J., Hassig, C. A., and Schreiber, S. L. (1996). Science 272, 408-411.
Week 4: Methylation and the Emergence of the "Histone Code"
Papers
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001). Nature 410, 116-120.
Wysocka, J., Swigut, T., Milne, T. A., Dou, Y., Zhang, X., Burlingame, A. L., Roeder, R. G., Brivanlou, A. H., and Allis, C. D. (2005). Cell 121, 859-872.
Week 5: Heritable Gene Expression
Papers
Rb targets histone H3 methylation and HP1 to promoters.
Nielsen, S. J., Schneider, R., Bauer, U. M., Bannister, A. J., Morrison, A., O'Carroll, D., Firestein, R., Cleary, M., Jenuwein, T., Herrera, R. E., and Kouzarides, T. (2001). Nature 412, 561-565
Ayyanathan, K., Lechner, M. S., Bell, P., Maul, G. G., Schultz, D. C., Yamada, Y., Tanaka, K., Torigoe, K., and Rauscher, F. J., 3rd (2003). Genes Dev 17, 1855-1869.
Week 6: Pluripotency Regulators & Stem Cell Differentiation
Papers
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
Chambers, I, Colby, D, Robertson, M, Nichols, J, Lee, S, Tweedle, S, & Smith, A. (2003). Cell 113, 643-655.
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H, Lieberam, I, Porter, JA, & Jessell, TM. (2002). Cell 110, 385-397.
