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'''[[Media:Class intro.ppt|Slides]]''' | '''[[Media:Class intro.ppt|Slides]]''' | ||
'''[http://www.nature.com/milestones/geneexpression/index.html An Extensive Review of the History of Gene transcription Research and Timeline of Milestones in This Field ]''' | |||
==Week 2: Chromatin Functions to Define Cell State== | ==Week 2: Chromatin Functions to Define Cell State== |
Revision as of 07:48, 18 October 2006
Week 1: Introduction
Week 2: Chromatin Functions to Define Cell State
Papers
Chromosomal Subunits in Active Genes Have an Altered Conformation
Weintraub, H & Groudine, M. (1976) Science 193, 848-856.
Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Meshorer, E, Yellajoshula, D, George, E, Scambler, PJ, Brown, DT, & Misteli, T. (2006) Dev Cell 10, 105-116.
Bonus Materials
Commentary on Meshorer et al paper
Supplemental Data for Meshorer et al paper
Obituary for Harold Weintraub from Molecular Biology of the Cell, 1995 (by Marc Kirschner)
Obituary for Harold Weintraub from Cell, 1995 (by Richard Axel & Tom Maniatis)
Week 3: Chromatin Structure and Discovery of Chromatin Modifying Enzymes
Papers
Brownell, J. E., Zhou, J., Ranalli, T., Kobayashi, R., Edmondson, D. G., Roth, S. Y., and Allis, C. D. (1996). Cell 84, 843-851.
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
Taunton, J., Hassig, C. A., and Schreiber, S. L. (1996). Science 272, 408-411.
Bonus Materials
Obituary of Alan Wolffe: Champion of Chromatin
Week 4: Methylation and the Emergence of the "Histone Code"
Papers
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., and Jenuwein, T. (2001). Nature 410, 116-120.
Wysocka, J., Swigut, T., Milne, T. A., Dou, Y., Zhang, X., Burlingame, A. L., Roeder, R. G., Brivanlou, A. H., and Allis, C. D. (2005). Cell 121, 859-872.
Bonus Materials
Histone Code and Chromatin Cross-Talk
Week 5: Heritable Gene Expression
Papers
Rb targets histone H3 methylation and HP1 to promoters.
Nielsen, S. J., Schneider, R., Bauer, U. M., Bannister, A. J., Morrison, A., O'Carroll, D., Firestein, R., Cleary, M., Jenuwein, T., Herrera, R. E., and Kouzarides, T. (2001). Nature 412, 561-565
Ayyanathan, K., Lechner, M. S., Bell, P., Maul, G. G., Schultz, D. C., Yamada, Y., Tanaka, K., Torigoe, K., and Rauscher, F. J., 3rd (2003). Genes Dev 17, 1855-1869.
Bonus Materials
Commentary on the Human Epigenome Project
Commentary on Kouzarides Paper
Week 6: Pluripotency Regulators & Stem Cell Differentiation
Papers
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
Chambers, I, Colby, D, Robertson, M, Nichols, J, Lee, S, Tweedle, S, & Smith, A. (2003). Cell 113, 643-655.
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H, Lieberam, I, Porter, JA, & Jessell, TM. (2002). Cell 110, 385-397.
Bonus Materials
Commentary on Chambers et al paper
Perspective on potential uses for ES cells and issues they raise
NIH report on prospects for neural regeneration using stem cells