7.342: Week 11 Questions

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7.342: Reading the Blueprint of Life: Transcription, Stem Cells, & Differentiation

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Post discussion, questions, or comments about the Week 10 course material here.

Amber

Elizabeth

Georgi

Grignani et al.

So PML and PLZF are fused to RARa and this causes improper repression of key genes involved in hematopoetic differentiation and consequently leukemia by oligomerization and enhanced NCoR/SMRT recruitment. What is the normal function of these proteins? Almost all I find is leukemia related

Holly

Kathy

Manpreet

Grigani et al:

Fig. 3b - The text says that constructs 6 and 7 demonstrate that the region 2158 - 2239 are required for optimal binding. Construct 11 contains this region, but still has a very low percentage of PZLF bound.

Okada et al: Fig. 2 - I don't understand why they show colocalization with staining instead of showing coimmunoprecipitation (as they do in Fig. 1)

Zak

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