7.342: Week 5 Questions

Post discussion, questions, or comments about the Week 5 course material here.

Amber

Elizabeth

Georgi

Holly

Kathy

Manpreet

Nielsen et al: In figure 1c, the control immunoprecipation (i.e. using the HA) shows some H3 methylase activity. I'm sure the activity shown isn't statisically significant, but I can't think of any reason for the control to show any activity.

Ayyanathan et al: The paper mentions two different homologs of HP1 - Alpha and Gamma. They also mention that HP1 Alpha is inducibly bound; and that HP1 gamma is constituitively bound. This is briefly mentioned again in the conclusion - have studies been done showing specific functioanl differences between the isoforms?

Zak

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