7.342: Week 9 Questions: Difference between revisions
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==Holly== | ==Holly== | ||
Takahashi et al: | |||
Fig 3c shows the methylation of the nanog promoter in iPs-MEFs to be much more similar to MEFs than ES cells. However fig 3a demonatres that nanog is expressed in the iPS cells. Does this suggest that DNA methylation plays only a minor role in silencing the gene? The pattern of methylation in iPS cells is different to in MEFs - is this just a result of the way the data is presented, or could changes in the pattern (and not the amount) of methylation explain how gene repression can be overcome? | |||
==Kathy== | ==Kathy== | ||
Revision as of 18:17, 8 November 2006
Post discussion, questions, or comments about the Week 8 course material here.
Amber
Elizabeth
Georgi
Holly
Takahashi et al: Fig 3c shows the methylation of the nanog promoter in iPs-MEFs to be much more similar to MEFs than ES cells. However fig 3a demonatres that nanog is expressed in the iPS cells. Does this suggest that DNA methylation plays only a minor role in silencing the gene? The pattern of methylation in iPS cells is different to in MEFs - is this just a result of the way the data is presented, or could changes in the pattern (and not the amount) of methylation explain how gene repression can be overcome?
Kathy
Manpreet
Zak
.
