Ahearne:Publications

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Publications

1. Prabhakar A, Lynch AP, Ahearne M. Self-assembled infrapatellar fat-pad progenitor cells on a poly-ε-caprolactone film for cartilage regeneration. Art Organs. (In press)
2. Ahearne M, Lynch AP. Early observations of extracellular matrix derived hydrogels for corneal stroma regeneration. Tissue Eng C 2015(In press; doi:10.1089/ten.TEC.2015.0008).
3. Wilson SL, Ahearne M, Hopkinson A. An overview of current techniques for ocular toxicity testing. Toxicology 2015; 327: 34-46.
4. Ahearne M, Lysaght J, Lynch AP. Combined influence of basal media and fibroblast growth factor on the expansion and differentiation capabilities of adipose derived stem cells. Cell Regen 2014; 3: 13.
5. Ahearne M. Introduction to cell-hydrogel mechanosensing. Interface Focus 2014; 4:20130038.
6. Ahearne M, Liu Y, Kelly DJ. Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair. Tissue Eng A 2014; 20(5-6): 930-939.
7. Lynch AP, Ahearne M. Strategies for developing decellularized corneal scaffolds. Exp Eye Res 2013; 108: 42-47.
8. Ahearne M, Kelly DJ. A comparison of fibrin, agarose and gellan gum hydrogels as carriers of stem cells and growth factor delivery microspheres for cartilage regeneration. Biomed Mater 2013; 8(035004): 1-10.
9. Wilson SL, Wimpenny I, Ahearne M, Rauz S, El Haj AJ, Yang Y. Chemical and topographical effects on cell differentiation and matrix elasticity in a corneal stromal layer model. Adv Funct Mater 2012; 22(17): 3641-3649.
10. Vinardel T, Rolfe RA, Buckley CT, Meyer EG, Ahearne M, Murphy P, Kelly DJ. Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells. Euro Cells Mater J 2012; 23: 121-134.
11. Ahearne M, Buckley CT, Kelly DJ. Chondrogenesis of infrapatellar fat-pad MSCs using TGF-ß1 loaded gelatin microspheres in fibrin hydrogels. Biotechnol Appl Biochem 2011; 58(5): 345-352.
12. Yang Y, Wimpenny I, Ahearne M. Portable nanofiber meshes dictate cell orientation throughout three-dimensional hydrogels. Nanomedicine NBM 2011; 7(2): 131-136.
13. Then KY, Yang Y, Ahearne M, El Haj AJ. Effect of microtopographical cues on human keratocyte orientation and gene expression. Cur Eye Res 2011; 36(2): 88-93.
14. Ahearne M, Liu KK, El Haj A, Then KY, Rauz S, Yang Y. Online monitoring of the mechanical behaviour of collagen hydrogels: Influence of corneal fibroblasts on elastic modulus. Tissue Eng C 2010; 16(2): 319-327.
15. Ahearne M, Wilson SL, Liu KK, El Haj AJ, Rauz S, Yang Y. Influence of cell and collagen concentration on the cell-matrix mechanical relationship in a corneal stroma wound healing model. Exp Eye Res 2010; 91(5): 584-591.
16. Li C, Ahearne M, Liu KK. Micromechanical characterizations of hydrogel based contact lens. Inter J Mod Phys B 2010; 24(1): 117-127.
17. Ahearne M, Siamantouras E, Yang Y, Liu KK. Mechanical characterization of biomimetic membranes by micro-shaft-poking. J R Soc Interface 2009; 6(34): 471-478.
18. Ahearne M, Yang Y, Then KY, Liu KK. Non-destructive mechanical characterization of UVA/riboflavin crosslinked collagen hydrogels. Br J Ophthalmol 2008; 92(2): 268-271.
19. Ahearne M, Bagnaninchi PO, El Haj AJ, Yang Y. Online monitoring of collagen alignment in tissue engineered tendon by PSOCT. J Tissue Eng Regen Med 2008; 2(8): 521-524.
20. Yang Y, Bagnaninchi P, Ahearne M, Wang R, Liu KK. A novel OCT-based micro-indentation technique for mechanical characterization of hydrogels. J R Soc Interface 2007; 4(17): 1169-1173.
21. Ahearne M, Yang Y, Then KY, Liu KK. An indentation technique to characterize the mechanical and viscoelastic properties of human and porcine corneas. Ann Biomed Eng 2007; 35(9): 1608-1616.
22. Ahearne M, Yang Y, El Haj AJ, Then KY, Liu KK. Characterizing the viscoelastic properties of thin hydrogel-based constructs for tissue engineering applications. J R Soc Interface 2005; 2(5): 455-463.

Book Chapters

1. Wilson SL, Ahearne M, El Haj AJ, Yang Y. The mechanical characterization of hydrogels and its implication on the cellular activities. In: Connon CJ, Hamley IW, Eds. Hydrogels in Cell-Based Therapies 2014; 8:171-190.
2. Ahearne M, Yang Y, Liu KK. Mechanical characterisation of hydrogels for tissue engineering applications. In: Ashammakhi N, Reis R, Chiellini, F, Eds. Topics in Tissue Engineering 2008; 4(12).

Conference Papers

1. Yang Y, Rupani A, Weightman A, Wimpenny I, Bagnaninchi P, Ahearne M. The study of optical properties and proteoglycan content of tendons by PS-OCT. Dynamics and Fluctuations in Biomedical Photonics VIII 2011; 7898-7.
2. Ahearne M, El Haj A, Rauz S, Yang Y. Online monitoring the mechanical remodeling of hydrogels by corneal fibroblasts. IFMBE Proceedings 2011; 30: 1-4.
3. Yang Y, Ahearne M, Wimpenny I, Guijarro-Leach J, Torbet J. Investigation of a tissue engineered tendon model by PSOCT. Optics in Tissue Engineering and Regenerative Medicine IV 2010; 7566.
4. Yang Y, Ahearne M, Wimpenny I, Torbet J. Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by PSOCT. Optics in Tissue Engineering and Regenerative Medicine III 2009; 7179.
5. Ahearne M, Liu KK, Yang Y. Dual-camera spherical indentation system for examining the mechanical characteristics of hydrogels. IFMBE Proceedings 2008; 22: 2011-2014.
6. Yang Y, Ahearne M, Bagnaninchi PO, Hu B, Hampson K, El Haj AJ. Application of polarization OCT in tissue engineering. Optics in Tissue Engineering and Regenerative Medicine II. 2008; 6858.
7. Liu KK, Ahearne M, Siamantouras E, Yang Y. Micro-shaft-poking - a novel instrument for mechanically characterizing soft biomimetic membrane. Biodevices 2008; 2: 210-215.
8. Yang Y, Bagnaninchi PO, Ahearne M, Wang RK, Liu KK. A novel OCT-based micro-indentation technique for mechanical characterization of soft tissues. Optics in Tissue Engineering and Regenerative Medicine I 2007; 6439.
9. Ahearne M, Yang Y, El Haj AJ, Then KY, Liu KK. A novel indentation technique for the mechanical characterization of human cornea. IFMBE Proceedings 2005; 11(1): 1885.

Conference Abstracts

1. Ahearne M. Fabrication of a hydrogel from extracellular matrix for corneal bioengineering. 21st Bioengineering in Ireland Conference, Carlton House Hotel, January 2015.
2. Lynch A, Ahearne M. Differentiation of adipose derived stem cells to keratocytes in vitro with retinoic acid. 21st Bioengineering in Ireland Conference, Carlton House Hotel, January 2015.
3. Wilson SL, Lynch A, Ahearne M. Investigating the use of dextran in corneal decellularization. Nottingham Eye Symposium and Research Meeting, United Kingdom, January 2015.
4. Ahearne M. Development of an ECM hydrogel for corneal tissue engineering. European Vision and Eye Research Congress, Nice, France, October 2014. Abstract published in ACTA Ophthalmologica; 92(s253).
5. Lynch A, Ahearne M. Growth factor regulation of keratocyte phenotype in serum free media. TERMIS-EU Annual Meeting, Genoa, Italy, June 2014. Abstract published in J Tissue Eng Regen Med 2014; 8(S1): 274.
6. Lynch A, Ahearne M. Control of corneal swelling during decellularization using dextran. TERMIS-EU Annual Meeting, Genoa, Italy, June 2014. Abstract published in J Tissue Eng Regen Med 2014; 8(S1): 451.
7. Lynch A, Ahearne M. The generation of a novel corneal scaffold using decellularized porcine corneas and human corneal keratocytes. 20th Annual Bioengineering in Ireland Conference, Limerick, January 2014.
8. Ahearne M, Lynch A. Extracellular matrix derived hydrogel for corneal tissue engineering. European Vision and Eye Research Congress, Nice, France, September 2013. Abstract published in ACTA Ophthalmologica.
9. Lynch A, O'Suillivan F, Ahearne M. Influence of growth factors on keratocyte phenotype in serum free media. European Vision and Eye Research Congress, Nice, France, September 2013. Abstract published in ACTA Ophthalmologica.
10. Ahearne M, Yurong L, Kelly DJ. A single stage therapy for articular cartilage repair using selected freshly isolated infrapatellar fat pad derived cells in a growth factor delivery hydrogel. Orthopaedic Research Society Annual Meeting, San Antonio, January 2013.
11. Lynch A, Ahearne M. Development of a decellularized scaffold for corneal tissue engineering. 19th Annual Bioengineering in Ireland Conference, Johnston House Hotel, January 2013.
12. Ahearne M, Kelly DJ. Development and optimization of a growth factor delivery hydrogel for cartilage regeneration. 3rd TERMIS World Congress, Vienna, Austria, September 2012. Abstract published in J Tissue Eng Regen Med 2012; 6(S1):185.
13. Almeida HV, Buckley CT, Cunniffe GM, Ahearne M, O‘Brien FJ, Kelly DJ. Combining freshly isolated CD271+ positive infrapatellar fat pad stem cells and a TGF-ß3 releasing scaffold to develop a single stage therapy for cartilage repair. 3rd TERMIS World Congress, Vienna, Austria, September 2012. Abstract published in J Tissue Eng Regen Med 2012; 6(S1):53.
14. Wimpenny I, Ahearne M Yang Y, Dictation of cell orientation throughout three dimensional hydrogels. 3rd TERMIS World Congress, Vienna, Austria, September 2012. Abstract published in J Tissue Eng Regen Med 2012; 6(S1):386.
15. Ahearne M, Kelly DJ. The chondrogenic potential of growth factor delivery microspheres is dependent on the hydrogel in which they are encapsulated. 18th Annual Bioengineering in Ireland Conference, Belfast, January 2012.
16. Almeida H, Buckley C, Cunniffe G, Ahearne M, Kelly DJ. Combining freshly isolated CD271+ positive infrapatellar fat pad stem cells and a TGF-ß3 releasing scaffold to develop a single stage therapy for cartilage repair. 18th Annual Bioengineering in Ireland Conference, Belfast, January 2012.
17. Buckley CT, Ahearne M, Downey R, Mulhall KJ, Kelly DJ. Engineering cartilage grafts using fibrin hydrogels seeded with diseased human infrapatellar fat pad derived stem cells. Orthopaedic Research Society Annual Meeting, San Francisco, February 2012.
18. Wimpenny I, Ahearne M Yang Y, Dictation of cell orientation throughout three dimensional hydrogels. 9th World Biomaterials Congress (WBC), Chengdu, China, June 2012.
19. Ahearne M, Buckley CT, Kelly DJ. Engineering a MSC seeded fibrin hydrogel containing TGF-beta 1 loaded gelatin microspheres for cartilage repair. TERMIS-EU Annual Meeting, Granada, Spain, 2011. Abstract published in Histol Histopathol 2011; 26(S1): 134.
20. Ahearne M, Buckley CT, Kelly DJ. TGF-ß1 loaded gelatin microspheres in fibrin constructs for chrondrogenic differentiation of MSCs. 17th Annual Bioengineering in Ireland Conference, Galway, January 2011.
21. Wilson SL, Ahearne M, Rauz S, El Haj AJ, Yang Y. Controlling corneal stromal cell phenotype via chemical cues. 12th Annual TCES Conference, Leeds, UK, July 2011. Abstract published in Euro Cells Mater J 2011; 22(S3): 35.
22. Ahearne M, El Haj AJ, Rauz S, Yang Y. Control of corneal fibroblast orientation and behaviour by nanofibers. 11th Annual TCES Conference, Manchester, UK, July 2010. Abstract published in Euro Cells Mater J 2011; 22(S2): 29.
23. Ahearne M, Wilson SL, Liu KK, AJ El Haj, S Rauz, Yang Y. Influence of cell number and collagen concentration on the mechanical behaviour of collagen hydrogels. Bioengineering 09, University of Oxford, October 2009.
24. Ahearne M, Wilson SL, Liu KK, El Haj A, Rauz S, Yang Y. Online monitoring of the mechano feedback loop between fibroblasts and their surroundings. 2nd TERMIS World Congress, Seoul, South Korea, September 2009.
25. Ahearne M, Liu KK, El Haj AJ, Rauz S, Yang Y. In vitro corneal stroma model for pharmaceutical screening and influence of corneal fibroblasts on elastic modulus. 9th Corneal Conference, Cardiff School of Optometry and Vision Sciences, July 2009.
26. Ahearne M, Wilson SL, Liu KK, El Haj AJ, Rauz S, Yang Y. Influence of cell number and collagen concentration on the mechanical behaviour of collagen hydrogel constructs. 10th Annual TCES Conference, Glasgow, UK, July 2009. Abstract publsihed in Euro Cells Mater J 2009; 18(S2): 21.
27. Ahearne M, Ladva E, Liu KK, El Haj A, Yang Y. Non-destructive monitoring of collagen degradation in tissue engineered corneal constructs. 9th Annual TCES Conference, Nottingham, UK, July 2008. Abstract published in Euro Cells Mater J 2008; 16(S3): 31.
28. Ahearne M, Liu KK, Yang Y. Online monitoring of MMP’s released by corneal fibroblasts in collagen hydrogels. 8th World Biomaterials Congress, Amsterdam, Netherlands, May 2008.
29. Ahearne M, Liu KK, El Haj A, Yang Y. Influence of corneal fibroblasts on the mechanical behavior of collagen hydrogels. TERMIS-NA Annual Meeting, San Diego, USA, December 2008.
30. Yang Y, Ahearne M, Bagnaninchi PO, El Haj AJ. Visualization of structural evolution in tissue engineering tendon. TERMIS-EU Annual Meeting, Porto, Portugal, June 2008. Abstract published in Tissue Eng A 2008; 14(5): 795.
31. Yang Y, Bagnaninchi PO, Ahearne M, Wang RK, Liu KK. A novel OCT-based micro-indentation technique for mechanical characterization of soft materials. Progress in Biomedical Optics and Imaging 2007; 8(16).
32. Ahearne M, Yang Y, El Haj AJ, Then KY, Liu KK. Mechanical characterization of tissue engineered corneal stroma. 5th World Congress of Biomechanics, Munich, Germany, July 2006. Abstract published in J Biomech 2006; 39: S226.
33. Ahearne M, Yang Y, El Haj AJ, Then KY, Liu KK. Mechanical characterisation of UVA-riboflavin crosslinked collagen hydrogels. 7th Annual TCES Conference, Sheffield, UK, July 2006. Abstract published in Euro Cells Mater J 2006: 11(S3): 72.
34. Ahearne M, Yang Y, El Haj AJ, Then KY, Liu KK. Mechanical characterisation and stimulation of corneal stroma equivalents. 6th Annual TCES Conference, London, UK, May 2005. Abstract published in Euro Cells Mater J 2005: 10(S2): 33.
35. Then KY, Ahearne M, Liu KK, Yang Y, Siamantouras E, McDonnell PJ, Shah S, Rauz, S, El Haj A. A new technique for mechanically characterising hydrogels for tissue engineering cornea. ARVO Annual Meeting, Fort Lauderdale, USA, May 2005. Abstract published in Invest Ophthalmol Vis Sci 2005; 46S: 2185.
36. Liu KK, Yang Y, Ahearne M, Then K, El Haj A. Mechanically characterizing and stimulating tissue-engineered corneal stromal equivalent. Inter J Exp Path 2005; 86: A29-A30.
37. Ahearne M, Yang Y, Then KY, El Haj AJ, Liu KK. A new technique for mechanical characterization in corneal tissue engineering. 5th World Cornea Congress, Washington DC, USA, April 2005.
38. Ahearne M, Liu KK, Yang Y, E Siamantouras, Then KY, El Haj AJ. A new technique for mechanically characterising hydrogels for tissue engineering cornea. Engineering in Regenerative Medicine Meeting, Liverpool, UK, November 2004.
39. Ahearne M, Liu KK, Yang Y, Then KY, El Haj AJ. Development of a new technique for mechanically characterising and stimulating tissue-engineered cornea. 5th Annual TCES Conference, Keele, UK, June 2004.
40. Ahearne M, Yang Y, Magnay J, Cooper J. Gene expression from osteoblasts cultured on poly-e-caprolactone based biodegradable biomaterials. 5th Annual TCES Conference, Keele, UK, June 2004.