Alcazar

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'''''Dear visitor,'''''<br>
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<br> Welcome to the webpage of the '''Molecular Genetics of Plant-Environment Interactions (Alcazar Lab)''' at the Department of Biology, Healthcare & Environment of the University of Barcelona. <br><br>
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We're a recently created research group that investigates the '''adaptation of plants to local environments'''. We focus on the evolutionary adaptation of plant populations to '''abiotic and biotic stresses''', which are major challenges for plant survival under the current climate change predictions. Derived from our research, we investigate ways for improving stress protection.<br>
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For a more detailed view of our research, please have a look at our [http://alcazar.openwetware.org/Research.html Research Projects] and [http://alcazar.openwetware.org/Publications.html Scientific Publications] sections. You can follow an updated list of our activities and publications in the NEWS section below. For any other enquires, do not hesitate to contact us directly.<br><br>
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[http://www.fv2017.org XXII Meeting of the Spanish Society of Plant Physiology, BCN 2017 26-29 June] <br>
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Info currently available in the following languages: <br>
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[[http://alcazar.openwetware.org EN]] [[http://alcazar_cat.openwetware.org CAT]] [[http://alcazar_es.openwetware.org ES]]
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'''''Plant-Environment Interactions and <br>Molecular Pharming'''''<br><br>
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'''1. MOLECULAR EVOLUTION OF DISEASE RESISTANCE IN PLANTS''' <br>
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Our lab studies the genetic and molecular bases for the adaptation of plants to their local environments. We mainly focus on the adaptation to stress (abiotic and biotic) and how this can be translated in an efficient molecular pharming (production of pharmaceutical compounds in plants) under the current challenges of climate change.
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In our lab, we make use of the extensive natural variation of [https://en.wikipedia.org/wiki/Arabidopsis_thaliana ''Arabidopsis thaliana''] populations to answer key fundamental questions:
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* '''How plants adapt to local environments including the microbiota?'''
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* '''How plants maintain variability of genes involved in pathogen recognition and to which extent this variability is caused by the interaction with pathogens?'''
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* '''How the environment manipulates immune responses? How this affects the above points?'''
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Current projects <br><br>
 
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'''Disease resistance in plants ''' <br>
 
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We're currently studying the evolution of ''NB-LRR'' immune-receptor genes and other interacting loci that condition defense against evolving pathogens and how this derives in immune-related hybrid incompatibility, an important obstacle in plant breeding. We address these questions using molecular biology, population genetics and biochemical approaches. This research is complemented by the study of the modulation of ''NB-LRR'' signaling by temperature which is important under the current climate change predictions.  <br><br>
 
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'''Natural variation of stress-induced metabolites''' <br>
 
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We study the genetic bases for the naturally occurring  variation of some stress metabolites involved in resistance traits to abiotic and biotic stresses in collaboration with different laboratories. We identify natural compounds which protect plants from stress. Through molecular approaches we improve the resistance of plants to different stresses. <br>
 
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'''Molecular pharming''' <br>
 
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We produce proteins of pharmaceutical interest in plants and study ways to improve their productivity under different environments to adapt to the requirements of local climates.
 
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To address these and other questions, we (and others) developed a new model for plant immunity studies based on the use of ''Arabidopsis'' immune-related incompatible hybrids. These are hybrids obtained by crosses of natural ''Arabidopsis'' accessions that exhibit constitutive activation of defense, stunted growth and sterility in the absence of pathogen challenge. Often, such phenotypes are temperature-dependent and suppressed at high temperature.
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For a more detailed view of our research, have a look at our [http://alcazar.openwetware.org/Research.html Research Projects] and [http://alcazar.openwetware.org/Publications.html Scientific Publications] sections. <br> For general public information have a look at [http://alcazar.openwetware.org/Alcazar_Youtube.html +info]. <br><br>
 
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These genetic interactions might unravel molecular partners required for proper modulation of defense. Some of these cases are background-dependent and therefore, likely difficult to be observed in classical reference accessions.
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[[Image:Announcement_alcazar.jpg |100px]] '''News and Announcements e-Board'''<br>
 
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'''NEW'''
 
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A 3-years PhD position (2015-2017) is available in our laboratory to study
 
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Arabidopsis ''NB-LRR'' evolution and interactions with ''Hyaloperonospora arabidopsidis'' pathogens.
 
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Interested candidates should send us their CV and two letters of reference by e-mail.
 
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Questions should be addressed to the same e-mail address below.
 
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Application period: 1 July - 15 September 2014
 
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Expected starting date: January 2015
 
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[mailto:ralcazar@ub.edu Contact]
 
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Since some years, we're using the Ler / Kas-2 immune-related hybrid incompatibility as molecular model to answer some of the questions above. The Landsberg (from Gorzów Wielkopolski, Poland)/Kashmir-2 (from Kashmir mountains) incompatibility involves populations in Central Europe and Central Asia which enable to expand our analyses to population scales. We apply population genetics on top of our molecular and biochemical analyses.
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Derived from our research, we attempt to provide new strategies for crop protection at medium to long-term.
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Latest publications: <br>
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Editorial article of upcoming e-book in Frontiers in Plant Science. Editors: Ruben Alcazar & A.F. Tiburcio.
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<br>
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[http://journal.frontiersin.org/Journal/10.3389/fpls.2014.00319/full Plant polyamines in stress and development: an emerging area of research in plant sciences] <br>
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'''2. Polyamines and plant stress protection'''
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'''The Roles of Polyamines during the lifespan of plants:from development to stress'''(2014).
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Polyamines are small amines present in living organisms. Polyamines are essential for cell viability and have co-evolved and participate in developmental and stress signalling pathways. We’re interested to know how polyamines exert their functions in plants, with a focus on stress tolerance. For this, we’re applying modern genetics, genomics and evolutionary biology. Our final goal is to provide new strategies for crop protection against different types of stress. Read our latest publication  on this topic [http://onlinelibrary.wiley.com/doi/10.1111/pce.12714/abstract here]. Most cited review (>450 times) [http://link.springer.com/article/10.1007%2Fs00425-010-1130-0?LI=true here]
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Tiburcio AF, Altabella T, Bitrián M and Alcázar R. Planta, doi: 10.1007/s00425-014-2055-9.  
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online first March 2014 [http://link.springer.com/article/10.1007/s00425-014-2055-9 read here]
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[[Image:Announcement_alcazar.jpg |100px]] '''News and Announcements e-Board'''<br>
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LATEST NEWS
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28.11.2016 Master offer just posted. Check out link for details. [http://openwetware.org/wiki/Alcazar:Master]
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Publications 2016
   
   
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<br><br>
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15/03/2016 In Frontiers Plant Sci: [http://journal.frontiersin.org/article/10.3389/fpls.2016.00401/abstract GWAS analysis for Arabidopsis guazatine tolerance]
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22/01/2016 In Plant Cell & Environment:  [http://www.ncbi.nlm.nih.gov/pubmed/26791972 tSpm triggers salinity tolerance in Arabidopsis]
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01/02/2016 In Frontiers Plant Sci: [http://journal.frontiersin.org/article/10.3389/fpls.2016.00173/abstract Metabolic profiling of atpao4 mutants under dark induced senescence]
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In press: Drought Stress Tolerance in Relation to Polyamine Metabolism in Plants, book chapter in Springer.
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''' ACADEMIC PRESS RELEASES'''<br>
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[http://www.ub.edu/web/ub/en/menu_eines/noticies/2015/01/020.html? Alcázar Lab work highlighted by the University of Barcelona 20.01.15]<br>
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[http://www.ub.edu/noticies/cgi/event.pl?id=62490&noticiaub=FARMACIA Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015]<br>
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[http://sefv.net/files/sd_publicaciones/58.pdf Alcázar Lab work highlighted by the Bulletin of the Spanish Society of Plant Physiology, SEFV. January, 2015]<br>
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[http://www.mpipz.mpg.de/4042700/PM_Parker_2015 PLoS Genet 2014 highlight by Max Planck Institute, Cologne. 11.12.14.]<br>
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[http://www.ub.edu/web/ub/en/menu_eines/noticies/2013/11/063.html? Arabidopsis semidwarfs: the green revolution in nature] 02.12.2013. University of Barcelona.<br>
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[http://www.mpipz.mpg.de/5389/news_publication_619091 Hybrid plants with over-reactive immune system] 17.11.2010. Max Planck Society.
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[http://www.ub.edu/farmacia/ The Faculty] | [http://www.ub.edu The University] | [http://bkc.upc.ub.edu/ The Campus] | [http://www.ccit.ub.edu/EN/home.html Scientific and Technological Centers]
 
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Full address: Facultat de Farmacia, Universitat de Barcelona, Unitat de Fisiologia Vegetal. Avda Joan XXIII 27-31, 08028 Barcelona (Spain). <br>
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Rubén Alcázar is Ramón y Cajal Researcher at the Department of Natural Products, Plant Biology and Soil Science of the [http://www.ub.edu University of Barcelona].<br>
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Tel +34 934 024 492 Fax +34 934 029 043 <br><br>
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<p>This wiki site is built under [http://www.openwetware.org Openwetware], an open access movement promoting the sharing of information among researchers.</p>
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<br>'''Research in Alcázar Lab is supported by:'''
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* 7th Framework Programme. Marie Curie Career Integration Grant (DISEASENVIRON, PCIG10-GA-2011-303568) of the European Union.
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* Ramón y Cajal Program (RYC-2011-07847) of the Ministerio de Ciencia e Innovación (Spain).
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* BFU2013-41337-P grant of the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia (Ministerio de Economía y Competitividad, Spain).
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Current revision




Dept. Biology, Healthcare & Environment
Section of Plant Physiology
Facultat de Farmàcia, Av. Joan XXIII 27-31
08028 Barcelona, Spain

Map


Dear visitor,

Welcome to the webpage of the Molecular Genetics of Plant-Environment Interactions (Alcazar Lab) at the Department of Biology, Healthcare & Environment of the University of Barcelona.

We're a recently created research group that investigates the adaptation of plants to local environments. We focus on the evolutionary adaptation of plant populations to abiotic and biotic stresses, which are major challenges for plant survival under the current climate change predictions. Derived from our research, we investigate ways for improving stress protection.

For a more detailed view of our research, please have a look at our Research Projects and Scientific Publications sections. You can follow an updated list of our activities and publications in the NEWS section below. For any other enquires, do not hesitate to contact us directly.

XXII Meeting of the Spanish Society of Plant Physiology, BCN 2017 26-29 June
Info currently available in the following languages:
[EN] [CAT] [ES]









1. MOLECULAR EVOLUTION OF DISEASE RESISTANCE IN PLANTS


In our lab, we make use of the extensive natural variation of Arabidopsis thaliana populations to answer key fundamental questions:

  • How plants adapt to local environments including the microbiota?
  • How plants maintain variability of genes involved in pathogen recognition and to which extent this variability is caused by the interaction with pathogens?
  • How the environment manipulates immune responses? How this affects the above points?


To address these and other questions, we (and others) developed a new model for plant immunity studies based on the use of Arabidopsis immune-related incompatible hybrids. These are hybrids obtained by crosses of natural Arabidopsis accessions that exhibit constitutive activation of defense, stunted growth and sterility in the absence of pathogen challenge. Often, such phenotypes are temperature-dependent and suppressed at high temperature.


These genetic interactions might unravel molecular partners required for proper modulation of defense. Some of these cases are background-dependent and therefore, likely difficult to be observed in classical reference accessions.


Since some years, we're using the Ler / Kas-2 immune-related hybrid incompatibility as molecular model to answer some of the questions above. The Landsberg (from Gorzów Wielkopolski, Poland)/Kashmir-2 (from Kashmir mountains) incompatibility involves populations in Central Europe and Central Asia which enable to expand our analyses to population scales. We apply population genetics on top of our molecular and biochemical analyses.


Derived from our research, we attempt to provide new strategies for crop protection at medium to long-term.




2. Polyamines and plant stress protection

Polyamines are small amines present in living organisms. Polyamines are essential for cell viability and have co-evolved and participate in developmental and stress signalling pathways. We’re interested to know how polyamines exert their functions in plants, with a focus on stress tolerance. For this, we’re applying modern genetics, genomics and evolutionary biology. Our final goal is to provide new strategies for crop protection against different types of stress. Read our latest publication on this topic here. Most cited review (>450 times) here



News and Announcements e-Board

LATEST NEWS
28.11.2016 Master offer just posted. Check out link for details. [1]


Publications 2016

15/03/2016 In Frontiers Plant Sci: GWAS analysis for Arabidopsis guazatine tolerance

22/01/2016 In Plant Cell & Environment:  tSpm triggers salinity tolerance in Arabidopsis

01/02/2016 In Frontiers Plant Sci: Metabolic profiling of atpao4 mutants under dark induced senescence

In press: Drought Stress Tolerance in Relation to Polyamine Metabolism in Plants, book chapter in Springer.

ACADEMIC PRESS RELEASES

Alcázar Lab work highlighted by the University of Barcelona 20.01.15
Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015
Alcázar Lab work highlighted by the Bulletin of the Spanish Society of Plant Physiology, SEFV. January, 2015
PLoS Genet 2014 highlight by Max Planck Institute, Cologne. 11.12.14.
Arabidopsis semidwarfs: the green revolution in nature 02.12.2013. University of Barcelona.
Hybrid plants with over-reactive immune system 17.11.2010. Max Planck Society.



Rubén Alcázar is Ramón y Cajal Researcher at the Department of Natural Products, Plant Biology and Soil Science of the University of Barcelona.



Research in Alcázar Lab is supported by:


  • 7th Framework Programme. Marie Curie Career Integration Grant (DISEASENVIRON, PCIG10-GA-2011-303568) of the European Union.
  • Ramón y Cajal Program (RYC-2011-07847) of the Ministerio de Ciencia e Innovación (Spain).
  • BFU2013-41337-P grant of the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia (Ministerio de Economía y Competitividad, Spain).

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