Amanda N. Wavrin Week 3: Difference between revisions
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*When searching HIV Virus on Google Scholar I got different results than when using PubMed. The Advanced Search option on Google Scholar was not very helpful. I did not get the same papers when I searched both sites but both resulted in interesting articles. | *When searching HIV Virus on Google Scholar I got different results than when using PubMed. The Advanced Search option on Google Scholar was not very helpful. I did not get the same papers when I searched both sites but both resulted in interesting articles. | ||
*When searching ISI Web of Knowledge I searched HIV Virus and specified articles from 2000-present. Once again I got different results from when I searched Google Scholar and PubMed. ISI appeared nicely organized. | *When searching ISI Web of Knowledge I searched HIV Virus and specified articles from 2000-present. Once again I got different results from when I searched Google Scholar and PubMed. ISI appeared nicely organized. | ||
====Terms and Definitions==== | |||
*Seroconversion- The change of a serologic test from negative to positive, indicating the development of antibodies in response to infection or immunisation. | |||
*Phyletic- Denoting the evolution of sequential changes in a line of descent by which one species is transformed into a new species. | |||
*Cohort- A cohort is a group of animals of the same species, indentified by a common characteristic, which are studied over a period of time as part of a scietific or medical investigation. | |||
*Epitopes- That part of an antigenic molecule to which the t cell receptor responds, a site on a large molecule against which an antibody will be produced and to which it will bind. | |||
*Epidemiology- The study of the distribution and determinants of health related states and events in populations and the control of health problems. | |||
*Hypervariable Region- The regions of the immunoglobulin molecule that contain most of the residues involved in the antibody binding site. | |||
*Virology- The study of viruses and viral diseases. | |||
*CD4 T cell- A form of T-lymphocyte with CD4 receptor on the cell surpface that recognizes antigens of a virus-infected cell. | |||
*Viral Load- The number of viral particles (usually HIV) in a sample of blood plasma. | |||
*PCR- Polymerase chain reaction. The first practical system for invitro amplification of DNA. | |||
Dictionary used: http://www.biology-online.org/dictionary/Main_Page |
Revision as of 21:58, 5 February 2010
Previous HIV Virus Knowledge
The be honest, my previous knowledge of the HIV virus is limited. I know that HIV is a virus and that it is sexually transmitted. I also know that there is no cure for HIV and that it is extremely difficult to treat. The evolution of the HIV virus is a hot topic and I know much research has been conducted revolving around its evolution. I do know that its origins are said to be in Africa and it is prevelent in Africa to this day.
Three questions about HIV that I would like to have answered are:
- What is the origin of the HIV viurs? Do we know its evolution?
- What are the effects of the HIV virus on the human body? What are the symptoms?
- What is the human immune system's response to the HIV virus once infected?
Using PubMed
- Begin by going to www.ncbi.nih.gov/entrez/
- Search dUTPase
- Clicking on the first article brings up a page with an abstract for the article
- By clicking on the hyperlink available for the author(s) it will conduct a search on PubMed for that author
- The screen shots shown for this page on PubMed today are different than those shown in the Bioinformatics for Dummies book used in lab.
- As seen on the screen above, there are no drop down boxes such an a "display" or "show" box
- Search by author name using the name Abergel
- Restrict your search results by adding dUTPase next to Abergel
- If large colored rectangle appear above the title, a journal offers free access to the full text for that paper
- You can aslo search PubMed using fields
- By clicking the drop down button next to the Display, you can click on MEDLINE
- In your search, if you follow each term by the code that identifies its field (in brackets) it will modify your search
- You can also limit your search by chosing the Advanced search link
Scholarly Review About the HIV Virus
- I searched PubMed to find a scholarly review by using the Advanced search option
- I selected the Review and English options to find this article:
- When searching HIV Virus on Google Scholar I got different results than when using PubMed. The Advanced Search option on Google Scholar was not very helpful. I did not get the same papers when I searched both sites but both resulted in interesting articles.
- When searching ISI Web of Knowledge I searched HIV Virus and specified articles from 2000-present. Once again I got different results from when I searched Google Scholar and PubMed. ISI appeared nicely organized.
Terms and Definitions
- Seroconversion- The change of a serologic test from negative to positive, indicating the development of antibodies in response to infection or immunisation.
- Phyletic- Denoting the evolution of sequential changes in a line of descent by which one species is transformed into a new species.
- Cohort- A cohort is a group of animals of the same species, indentified by a common characteristic, which are studied over a period of time as part of a scietific or medical investigation.
- Epitopes- That part of an antigenic molecule to which the t cell receptor responds, a site on a large molecule against which an antibody will be produced and to which it will bind.
- Epidemiology- The study of the distribution and determinants of health related states and events in populations and the control of health problems.
- Hypervariable Region- The regions of the immunoglobulin molecule that contain most of the residues involved in the antibody binding site.
- Virology- The study of viruses and viral diseases.
- CD4 T cell- A form of T-lymphocyte with CD4 receptor on the cell surpface that recognizes antigens of a virus-infected cell.
- Viral Load- The number of viral particles (usually HIV) in a sample of blood plasma.
- PCR- Polymerase chain reaction. The first practical system for invitro amplification of DNA.
Dictionary used: http://www.biology-online.org/dictionary/Main_Page