Amanda N. Wavrin Week 9
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HIV Structure Research Project
Proposed Research Questions
- Will there be specific differences in the protein sequences of subjects 10 and 12 that will result in different structures and different functions?
Methods
- We chose subjects 10 and 12 because they had a wide range of CD4 T cell rates
- Subject 10 had the largest decrease in CD4 T cell counts. Of the rapid progressors in our previous project, subject 10 had the most visits.
- We chose subject 12 because it had an average rate of CD4 T cell increase within the nonprogressors
- We decidced to use all the clones for visits 4 and 5 of each subject because both subjects were present for that visit and there are a total of 42 sequences.
- We used biology workbench run a CLUSTALW multiple sequence alignment
