Angela A. Garibaldi Week 3: Difference between revisions
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=== 10 Biological Terms=== | === 10 Biological Terms=== | ||
#'''seroconverting'''- '''serotype'''- The genotype of a unicellular organism as defined by antisera against antigenic determinants expressed on the surface. Therefore; the conversion of the serotype.[http://www.mblab.gla.ac.uk/%7Ejulian/Dict.html Dictionary of Cell and Molecular Biology] | #'''seroconverting'''- '''serotype'''- The genotype of a unicellular organism as defined by antisera against antigenic determinants expressed on the surface. Therefore; the conversion of the serotype.[http://www.mblab.gla.ac.uk/%7Ejulian/Dict.html Dictionary of Cell and Molecular Biology] | ||
#'''non-synonymous mutation- a.k.a. a missense mutation''' -A form of point mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during translation. [http://www. | #'''non-synonymous mutation- a.k.a. a missense mutation''' -A form of point mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during translation. [http://www.biology-online.org/dictionary/Main_Page biology-online.org dictionary] | ||
#'''CD4 T-Cells-''' A form of T lymphocyte with CD4 receptor on the cell surface that recognizes antigens of a virus-infected cell. This type of T lymphocyte releases lymphokines upon stimulation of its recognition of antigens of a virus-infected cell. Upon its antigen recognition it is activated, stimulating, in turn, B lymphocytes and killer T lymphocytes during the antibody formation.It is the target cell of AIDS virus, infecting and eventually killing the lymphocyte by the virus. [http://www.biology-online.org/dictionary/Main_Page biology-online.org dictionary] | |||
#'''CD4-''' A 55-kD glycoprotein that serves as differentiation antigen found on the surface of T lymphocytes and macrophages. The CD in CD4 is an abbreviation for cluster of differentiation. It belongs to the immunoglobulin supergene family. The presence of CD4 characterizes the helper/inducer cell. It also serves as HIV receptors where the virus binds directly with its envelope protein gp120. [http://www.biology-online.org/dictionary/Main_Page biology-online.org dictionary] | |||
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Revision as of 21:14, 6 February 2010
Prior knowledge of the HIV virus:
- Currently I don't know very much about the biological aspects of the HIV virus. I only know that it makes the immune system very weak and is a RNA retro virus.
- The following are questions about HIV I would like answered:
- What is the overall molecular mechanism of the disease?
- What type of virus is it specifically and what does this imply?
- What are the mechanisms of some of the methods of treatment currently used?
"Becoming an Expert in Pubmed"
Note: Version of Pubmed used is The following are the searching processes used to find review articles relevant to answering the above questions:
- My first search query was: HIV [TI] evolution Limits:links to free full text, abstracts review, english.
- [TI] specifies that only papers with "HIV" in the title of any papers.
- I've highlighted the PubMed ID number of the article that I chose. This is what is used to complete the bibliography code and used to easily find the paper again.
- The following review seemed most relevant and clear as an introductory paper
- Cohen MS, Hellmann N, Levy JA, DeCock K, and Lange J. The spread, treatment, and prevention of HIV-1: evolution of a global pandemic. J Clin Invest. 2008 Apr;118(4):1244-54. DOI:10.1172/JCI34706 |
Further Articles for Investigation:
- Williams KC and Burdo TH. HIV and SIV infection: the role of cellular restriction and immune responses in viral replication and pathogenesis. APMIS. 2009 May;117(5-6):400-12. DOI:10.1111/j.1600-0463.2009.02450.x |
Markham Article
10 Biological Terms
- seroconverting- serotype- The genotype of a unicellular organism as defined by antisera against antigenic determinants expressed on the surface. Therefore; the conversion of the serotype.Dictionary of Cell and Molecular Biology
- non-synonymous mutation- a.k.a. a missense mutation -A form of point mutation resulting in a codon that codes for a different amino acid, and thus, causes the synthesis of a protein with an altered amino acid sequence during translation. biology-online.org dictionary
- CD4 T-Cells- A form of T lymphocyte with CD4 receptor on the cell surface that recognizes antigens of a virus-infected cell. This type of T lymphocyte releases lymphokines upon stimulation of its recognition of antigens of a virus-infected cell. Upon its antigen recognition it is activated, stimulating, in turn, B lymphocytes and killer T lymphocytes during the antibody formation.It is the target cell of AIDS virus, infecting and eventually killing the lymphocyte by the virus. biology-online.org dictionary
- CD4- A 55-kD glycoprotein that serves as differentiation antigen found on the surface of T lymphocytes and macrophages. The CD in CD4 is an abbreviation for cluster of differentiation. It belongs to the immunoglobulin supergene family. The presence of CD4 characterizes the helper/inducer cell. It also serves as HIV receptors where the virus binds directly with its envelope protein gp120. biology-online.org dictionary