Angela A. Garibaldi Week 3

Prior knowledge of the HIV virus:

• Currently I don't know very much about the biological aspects of the HIV virus. I only know that it makes the immune system very weak and is a RNA retro virus.
• The following are questions about HIV I would like answered:
  • 1. What is the overall molecular mechanism of the disease?
    2. What type of virus is it specifically and what does this imply?
    3. What are the mechanisms of some of the methods of treatment currently used?

"Becoming an Expert in Pubmed"

Note: Version of Pubmed used is The following are the searching processes used to find review articles relevant to answering the above questions:

1. My first search query was: HIV [TI] evolution Limits:links to free full text, abstracts review, english.

• [TI] specifies that only papers with "HIV" in the title of any papers.

• I've highlighted the PubMed ID number of the article that I chose. This is what is used to complete the bibliography code and used to easily find the paper again.

• The following review seemed most relevant and clear as an introductory paper

1. Cohen MS, Hellmann N, Levy JA, DeCock K, and Lange J. The spread, treatment, and prevention of HIV-1: evolution of a global pandemic. J Clin Invest. 2008 Apr;118(4):1244-54. DOI:10.1172/JCI34706 |

Further Articles for Investigation:

1. Williams KC and Burdo TH. HIV and SIV infection: the role of cellular restriction and immune responses in viral replication and pathogenesis. APMIS. 2009 May;117(5-6):400-12. DOI:10.1111/j.1600-0463.2009.02450.x |