Ani Arun and Shirley Galbiati 20.109 Proposal: Difference between revisions
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=== Scientific Questions and Engineering Goals === | === Scientific Questions and Engineering Goals === | ||
Inspired by the Hasty lab synchronized oscillator, we would like to construct a synchronized oscillator in mammalian cells. We would like to use this synchronized oscillator to form static spatial patterns of gene expression, as occurs naturally in the vertebrate segmentation process. Our project could shed light on the key processes that govern the vertebrate segmentation in development, as well as serve as a starting point for programmed patterned tissue formation and other applications in regenerative medicine. | Inspired by the Hasty lab synchronized oscillator, we would like to construct a synchronized oscillator in mammalian cells. We would like to use this synchronized oscillator to form static spatial patterns of gene expression, as occurs naturally in the vertebrate segmentation process. Our project could shed light on the key processes that govern the vertebrate segmentation in development, as well as serve as a starting point for programmed patterned tissue formation and other applications in regenerative medicine. | ||
In our implementation of the system, we would rely on fluorescent proteins as the readout of cell state. Experimental verification of our system would require time-lapse quantitative imaging techniques. | In our implementation of the system, we would rely on fluorescent proteins as the readout of cell state. Experimental verification of our system would require time-lapse quantitative imaging techniques. |
Revision as of 08:14, 27 April 2011
Research Proposal Brainstorming
Scientific Questions and Engineering Goals
Inspired by the Hasty lab synchronized oscillator, we would like to construct a synchronized oscillator in mammalian cells. We would like to use this synchronized oscillator to form static spatial patterns of gene expression, as occurs naturally in the vertebrate segmentation process. Our project could shed light on the key processes that govern the vertebrate segmentation in development, as well as serve as a starting point for programmed patterned tissue formation and other applications in regenerative medicine.
In our implementation of the system, we would rely on fluorescent proteins as the readout of cell state. Experimental verification of our system would require time-lapse quantitative imaging techniques.