# Ashley Rhoades Week 2

### From OpenWetWare

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In this model the inflow rate, concentration inflow, growth rate, saturation, and consumption are all parameters. The dependent variables are the nutrient concentration and cell population and these are functions of time. There is one differential equation for the change in the nutrient concentration and one for the change in cell population over the change in time. By putting the differential equations into MATLAB the cell population and nutrient concentration can be observed given different parameters. For this first model I played with the five parameters mentioned earlier. After inputting different values I wanted to see what each parameter did to the cell population and nutrients when increased dramatically, while keeping the other parameters constant. The base values I used for each was 1 and for the consumption rate(or waste production) it was 0.1. When I changed the inflow rate from 1 to 10 I observed that the cell population approached zero and the nutrient levels increased. This result was more apparent when I increased the inflow rate to 100 volume units per unit time. Because we are at a constant volume in the chemostat this makes sense because inflow increasing the outflow and the cells aren't growing fast enough to maintain their population. | In this model the inflow rate, concentration inflow, growth rate, saturation, and consumption are all parameters. The dependent variables are the nutrient concentration and cell population and these are functions of time. There is one differential equation for the change in the nutrient concentration and one for the change in cell population over the change in time. By putting the differential equations into MATLAB the cell population and nutrient concentration can be observed given different parameters. For this first model I played with the five parameters mentioned earlier. After inputting different values I wanted to see what each parameter did to the cell population and nutrients when increased dramatically, while keeping the other parameters constant. The base values I used for each was 1 and for the consumption rate(or waste production) it was 0.1. When I changed the inflow rate from 1 to 10 I observed that the cell population approached zero and the nutrient levels increased. This result was more apparent when I increased the inflow rate to 100 volume units per unit time. Because we are at a constant volume in the chemostat this makes sense because inflow increasing the outflow and the cells aren't growing fast enough to maintain their population. | ||

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+ | [[Image: Constants.jpg|Before changing parameters]] | ||

Next when I changed the nutrient concentration of the inflow the nutrients slowly surpassed the cell population. Then when I put 100 of some concentration units in for the inflow concentration the cell population again did not change but the nutrient population sky rocket. Since there's only so many cells with the other parameters like population growth rate are low the cell population cannot grow much even with nutrients increased. So when I did dramatically increase the growth rate, and left the other values low, the nutrient levels dropped to zero. The level of saturation of nutrients had little effect of the cell population and nutrient levels. | Next when I changed the nutrient concentration of the inflow the nutrients slowly surpassed the cell population. Then when I put 100 of some concentration units in for the inflow concentration the cell population again did not change but the nutrient population sky rocket. Since there's only so many cells with the other parameters like population growth rate are low the cell population cannot grow much even with nutrients increased. So when I did dramatically increase the growth rate, and left the other values low, the nutrient levels dropped to zero. The level of saturation of nutrients had little effect of the cell population and nutrient levels. |

## Revision as of 21:37, 24 January 2013

## Chemostat Model

### Part 1: Nutrient/Cell Population Model

In this model the inflow rate, concentration inflow, growth rate, saturation, and consumption are all parameters. The dependent variables are the nutrient concentration and cell population and these are functions of time. There is one differential equation for the change in the nutrient concentration and one for the change in cell population over the change in time. By putting the differential equations into MATLAB the cell population and nutrient concentration can be observed given different parameters. For this first model I played with the five parameters mentioned earlier. After inputting different values I wanted to see what each parameter did to the cell population and nutrients when increased dramatically, while keeping the other parameters constant. The base values I used for each was 1 and for the consumption rate(or waste production) it was 0.1. When I changed the inflow rate from 1 to 10 I observed that the cell population approached zero and the nutrient levels increased. This result was more apparent when I increased the inflow rate to 100 volume units per unit time. Because we are at a constant volume in the chemostat this makes sense because inflow increasing the outflow and the cells aren't growing fast enough to maintain their population.

Next when I changed the nutrient concentration of the inflow the nutrients slowly surpassed the cell population. Then when I put 100 of some concentration units in for the inflow concentration the cell population again did not change but the nutrient population sky rocket. Since there's only so many cells with the other parameters like population growth rate are low the cell population cannot grow much even with nutrients increased. So when I did dramatically increase the growth rate, and left the other values low, the nutrient levels dropped to zero. The level of saturation of nutrients had little effect of the cell population and nutrient levels.

Since the consumption rate started at only 0.1 I just rose it to 2 and then 100. With the increase to 2 the cell population increased and then began falling, in accordance with the minimal nutrients available. When I raised it to 100 the bump in the cell population is more exaggerated and the nutrient levels drop quickly.