BIOL367/F10:Class Journal Week 7

Salomon Garcia

• How do you think biotechnology like whole genome sequencing and microarrays will affect your future?---- I thing that genome sequencing and microarrays will affect my future and that is because there will be many species that will have there entire genome sequenced to it's entirety which will enable us to learn many new aspects that were once unknown to us. I feel that the future with genome sequencing and microarrays will bring us a new age of understanding.
• How will it affect your career?---- I think that this will affect my career in a good way because it will enable us to learn of species in ways that will increase our knowledge and it will help us in there understanding and how they function.
• How will it affect your personal life?---- I think that it will affect it for the better, personally I feel that technology in general helps us live better and greater lives. I do feel though that technology is pulling us away from certain tasks that could still be done manually.
• What pitfalls can you forsee and how would you suggest avoiding them?---- Some of the pitfalls I see are concerning certain aspects of information that are seen and where this information may get to. I feel that this information can certainly be accessed by anyone then there will be a problem.

Salomon Garcia Valencia 20:01, 17 October 2010 (EDT)

Link to Journal Club Presentation for Tuesday 10/19/2010

Andrew Herman

1. How do you think biotechnology like whole genome sequencing and microarrays will affect your future?- It is likely that within the next decade, the price of individual DNA sequencing will have dropped to a point that it will become a viable tool for medical diagnostics, and development of effective treatment, of most known diseases. My entire genome will be available for sequencing and then analysis within a relatively quick time span, say a week. And this will give medical professionals the ability to be more precise and accurate in their treatment of complicated illness, that I may develop, similar to the way MRI and Pet scan test are used today. This technology has the potential to change the way medicine is practiced, in that every person will be sequenced and their data analyzed for treatment options. Biotech development is on the front line of the battle with deadly illnesses such as cancer, and has the highest possibility of becoming the tool with which effective treatment is developed.
2. How will it affect your career?- With advancement in any technological field, creation of new and highly competitive professional positions will become available to be filled by those knowledgeable in the necessary skills. A fundamental knowledge of DNA microarray technology with an ability to analyze the data on a large scale quickly, enables a person to become more competitive in these fields. Thus, new career opportunities are likely to become available at an ever expanding rate. There is also room for entrepreneurship, with new and expanding companies being developed at an exponential level, there will be several services currently unavailable that can lay the foundations of new companies; making this technology more commonly available and relevant to the average person.
3. How will it affect your personal life?- Personally, a technology such as this would make future medical treatment far more effective and efficient, in terms of prediction, diagnosis, and treatment options. If I or a close friend/family member were susceptible to a disease, the increased ability in prognosis and treatment would make it more likely that the personal relation would survive longer and have a higher quality of life. An important factor to anyones personal life, is his personal relationships, and the quality of life that they can all experience.
4. What pitfalls can you foresee and how would you suggest avoiding them?- The major danger with this type of technological development mostly stems from an issue of privacy. Privacy for patients, whom may have a serious diagnosis found in their analysis, would become a hot topic issue with its development. This would stem from possible discrimination claims, by persons, who feel that their particular position will be threatened if their employer discovered the results of their test. Especially in a climate where health care rights is such a hot button issue, this type of developing technology could come under attack by groups that are concerned with privacy rights of patients. Another, even more dangerous, problem for a technology such as this is cost availability. Will this form of treatment be available to all, rich and poor, paid for by the government, or will it be considered a luxury type of test available for the wealthy and middle class. Separations in quality healthcare to socio economic classes would become further divided in a situation such as described. These are just a few of the social issues, that could be foreseen, not to mention the accuracy and effectiveness of mass testing that would tax the medical infrastructure in this country.

Andrew Herman 17:31, 17 October 2010 (EDT) Powerpoint Presentation

Richard Brous

1. How do you think biotechnology like whole genome sequencing and microarrays will affect your future? - I have no doubt individual (human) sequencing will arise as a viable business as soon as the price drops below $1000. And with all the individual and human comparison information (dna strengths and weaknesses) there will be those who would like to use that information to their advantage at the expense of the individual. The likely groups will be employers, insurance companies, wealthy families and probably more. Employers might only want those healthy enough to lower their benefit premiums and show higher IQ or possibly physical strenth. Insurance companies who already employ significant statistical analysis will add in "gene weaknesses" and try to avoid those who carry characteristics which they deem unfavorable. Weathly families will scan their childrens pool of suiters to ensure "strong stock" enters into their family line. The whole while all parties will either ignore or simply be unaware that environmental factors have significant and random effects over time. So I feel that this could and likely will significantly impact my future.
2. How will it affect your career? - I'm not sure, certainly there may be interesting opportunities as a computer scientist to write algorithms and software to support the needs of this new industry. So maybe a job for me down the road in this area helping to standardize data collection and usage across various databases, not to mention opportunities in analysis and tool development.
3. How will it affect your personal life? - This will be another area where I will be ever vigilant to protect the security of personal sequencing data as I would my social security number. Not just for myself, but for my family and close friends who won't likely have spent the time to understand how dangerous the downside could be. On the other hand would this prevent me from having my own sequencing performed? Probably not... I think insight into my physiology would provide a peek into my long term viability. It could potentially provide insight into my and my offsprings succeptibility to certain disease and illness.
4. What pitfalls can you forsee and how would you suggest avoiding them? - Lock up your data. Ensure the organization who provides the sequencing and analysis services can guarantee your personal data will not exist over time in their possession (server or database). Keep an eye on legislation which may weaken our individual rights to keep our data private. The last thing we need is a public sequencing service to keep track of individuals which business has access to, similar to the credit bureaus or govt tracking by social security number. We must prevent aggregation of this data... period.

15:06, 17 October 2010 (EDT)

Andrew Forney

1. How do you think biotechnology like whole genome sequencing and microarrays will affect your future? This seems to be a question of nature vs. nurture at the most fundamental level; while whole-genome sequencing and microarrays may some day be able to provide complete, predictive information about events, personas, and conditions in a person's future, the person's subsequent interaction with the outside world may change these predicted outcomes. As such, because there is this level of uncertainty and because people in a democracy would most likely only allow this process to influence them up to a point, I foresee this biotechnology serving as helpful, but not damning, warnings as to a person's future genetic events.
2. How will it affect your career? As I note above, and because apparently there is some legislation even as we speak to protect peoples' jobs despite found genetic qualities, the only way this biotechnology could influence my career is if I internalized the presented information about my future and then made career decisions based upon it--I doubt that there will be outside forces to act against or for me based upon my genetic makeup as this brings into question ethical issues as well (watch any dystopian science fiction movie and you might see that our future has already been cognitively warded against such a fate).
3. How will it affect your personal life? In this manner I could see the predictive nature of this biotechnology having some influence; for example, if a person knew they had a predisposition to heart disease, they might exercise more than they would have without this knowledge. In a way, this is the old question of, "If you could be told how you were going to die, would you want to know?" For some people, ignorance would be bliss, and as such they might not even want this data.
4. What pitfalls can you forsee and how would you suggest avoiding them? Apropos of what I say in the last question, who knows what sort of psychological instability this predictive information might cause? Again, suppose a person is told they have a predisposition to heart disease; henceforth, every little twinge in their chest, every case of heartburn, or any muscle cramp might send them into a panic for fear of a heart attack--it could potentially be the birth of widespread paranoia. Furthermore, consider the tax on our medical personnel; I foresee waiting rooms packed more to the brim because people, gaining a glimpse into their future fate, are grasped by fear that death awaits around every corner (I hyperbolize for rhetorical effect, but you get the picture). As such, perhaps this information should be on a "need to know" basis; patients who are in no immediate or definite risk should not be told of their possible future afflictions unless it is a pressing, life-threatening concern. Then again, it would probably throw into fuss a whole "freedom of information" argument and the politicians will have a field day over the issue... so who knows what consequences could arise from our work in biotechnology--for now, it's simple debate over hypotheticals.

Andrew Forney 21:12, 17 October 2010 (EDT)

Jennifer Okonta

1. How do you think biotechnology like whole genome sequencing and microarrays will affect your future? Yes, it will affect my future because since I am pursuing a career in the medical field this could change the way people will find out about their future medical health. Patients will be able to see and know what they are at risk for and we will be able to catch certain diseases and illnesses way in advance before the patient even has a chance to get sick for it.
2. How will it affect your career? This will affect my career because it will make it easier for us to treat patients and diagnose them based on their genes. We would not have to rely much on genetic history and other past medical files. The person's genome sequencing will be able to answer all of the questions needed to find out about the person's medical history.
3. How will it affect your personal life? It will affect my personal life because I will be able to find out about my own personal genome sequence if I really need it and that could make it easier for me to know what illnesses I am at risk for.
4. What pitfalls can you forsee and how would you suggest avoiding them? That the genome sequencing may not always be right. The machine may make mistakes and sometimes make up completely wrong sequences which can happen because it is a computer doing the work. So that is one pitfall that is always expected.

Theresa Graebener

1. How do you think biotechnology like whole genome sequencing and microarrays will affect your future?-- I think that in the future biotechnology is going to change my life dramatically. Since I want to be a doctor, I try to keep updated on some major findings in biotechnology, and I think that the even the things we can do today (prosthetics in particular) are life changing. If genome sequencing ever becomes affordable, I think it will change the face of healthcare, since people will know what diseases they are genetically inclined to get, and will try using a more preventive approach to their health than treating the problem.
2. How will it affect your career?--I want to be an orthopedic surgeon when I am a doctor, and biotechnology has already helped advance this field tremendously. Surgeries are less evasive therefore recovery time has decreased. Genome sequencing will add to our knowledge about the human body, and hopefully lead to cures for cancer and some diseases.
3. How will it affect your personal life?--If genome sequencing became affordable, I would want to get my genome sequenced. I would want to know if there was a particular illness I was going to eventually get, and try to delay it as much as possible.
4. What pitfalls can you forsee and how would you suggest avoiding them?-- I think the only pitfalls would be insurance providers charging more if their patients' genome put them at a risk for getting a disease. I think that would be unethical for insurance prices to increase because they see larger medical expenses in the future.

--Theresa Graebener 20:55, 17 October 2010 (EDT)

Evan Montz

• How do you think biotechnology like whole genome sequencing and microarrays will affect your future?-- If I do end up going into the field of bioengineering, there is a definite possibility that I could be working with genome sequencing and microarrays. If genome sequencing becomes cheaper, there is a possibility that sequencing could become a medical norm and could affect everyone's lives.
• How will it affect your career?-- This will depend on if I choose to pursue bioengineering and if I select a field within bioengineering that deals with genomics. I anticipate that this will be an enormous field of interest in years to come, so it could definitely affect my career.
• How will it affect your personal life?-- If genome sequencing becomes cheap enough and ends up being as helpful as scientists think it might, it could drastically affect the lives of millions. I suppose it has the potential to diagnose diseases early and to directly affect my individual life.
• What pitfalls can you forsee and how would you suggest avoiding them?-- I'm guessing the success of sequencing will depend on the laws that get put in place to protect the people that get a genome sequence for them-self. I think that the lawmakers will have to be very careful while creating the laws in order to prevent a lot of identity issues. There will have to be a way of ensuring that people cannot be discriminated against in any way based on their DNA sequence. Genetic information will have to be very confidential.

Evan Montz 00:03, 18 October 2010 (EDT)

Claudia Campos

1. How do you think biotechnology like whole genome sequencing and microarrays will affect your future? Biotechnologies can only progress from now on and they'd be more available in the future. Genome sequencing will be something that would pose as a possibility for me to utuilize, that is I could get my genome sequenced and find out what illnesses I'm prone to among other such information.
2. How will it affect your career? The progression and understanding of biotchnologies will give me more material as a teacher to teach along with any research findings that used biotchnologies.
3. How will it affect your personal life? I'd have to make the choice of whether I want my genome sequenced or not. That would be a big decision because so much information about myself will be known that I could've never known before. It just seems like I'd be overwhelmed by the information, but at the same time amazed.
4. What pitfalls can you forsee and how would you suggest avoiding them? When it comes to genome sequencing, I was already aware of ethical debates surrounding it. I didn't want to get my genome sequenced if that meant there was a possibility of people discriminating against me or it being a determining factor in whether or not I get a job. Dr. Dahlquist made me aware of the law that says that that sort of discrimination can't be done, which took that fear away. This should be confidential information like a person's social security number is.

Claudia Campos 01:36, 18 October 2010 (EDT)

Zeb Russo

• How do you think biotechnology like whole genome sequencing and microarrays will affect your future? - I remember reading recent articles about a new field opening up called synthetic biology where Venter stitched together a genome from scratch and it operated a cell. I thought this was really interesting and where biotechnology will go.
  • How will it affect your career? - Since I want to be a doctor... probably no direct changes, at least within twenty years. Maybe in thirty I will start to see biotechnology really entering as another way to cure various diseases and cancers.
  • How will it affect your personal life? - Well I'll certainly benefit in my old age, because by then they will hopefully have a way to make new organs and cure most cancers using some form of biotechnology.
  • What pitfalls can you forsee and how would you suggest avoiding them? - It reminds me of when Oppenheimer saw the devestation from the trinity test and realized the potentiality of nuclear power for constructive and destructive uses. It will be the same for this, it can be used for both good and evil, it just matters on the person using it.

Zeb Russo 01:21, 18 October 2010 (EDT)

Margie Doyle

• How do you think biotechnology like whole genome sequencing and microarrays will affect your future?
  • I think as it becomes increasingly more financially feasible, applications of the technology will be more and more present in our lives.
• How will it affect your career?
  • I don't really see it ever affecting my career, because it isn't a field I am particularly interested in getting into.
• How will it affect your personal life?
  • I don't think it will, because I don't intend to get any kind of genetic testing and I'm not into anything that engineered going into my body.
• What pitfalls can you forsee and how would you suggest avoiding them?
  • I think anytime you start to manipulate and try to dominate nature, you tend to ruin it and create long-lasting issues. I think that we may be getting a little bit ahead of ourselves, and that all of this growing info can fall into the wrong hands.

Margie Doyle 02:53, 18 October 2010 (EDT)