BISC220/S10: Lecture Syllabus - Revision history

Melissa Beers: /* BISC220 Cell Physiology */

2010-01-21T20:18:52Z

BISC220 Cell Physiology

←Older revision		Revision as of 20:18, 21 January 2010
Line 15:		Line 15:
	Office Hours: by arrangement (SC175) <br><br>		Office Hours: by arrangement (SC175) <br><br>

-	'''Lectures:''' Tuesdays & Fridays 11:10-12:20 SC396<br>	+	'''Lectures:''' Tuesdays & Fridays 11:10-12:20 (SC396)<br>
-	'''Labs:''' : Tues. 12:30-4; Wed. 2:15-5:45; Thurs. 1-4:30 SC304<br>	+	'''Labs:''' : Tues. 12:30-4; Wed. 2:15-5:45; Thurs. 1-4:30 (SC304)<br>
	<br>		<br>
	'''Text:''' Alberts, B. et al. (2008) ''Molecular Biology of the Cell'', 5th ed., Garland Science<br>		'''Text:''' Alberts, B. et al. (2008) ''Molecular Biology of the Cell'', 5th ed., Garland Science<br>

Melissa Beers: /* BISC220 Cell Physiology */

2010-01-21T20:18:20Z

BISC220 Cell Physiology

←Older revision		Revision as of 20:18, 21 January 2010
Line 6:		Line 6:
	'''Lab Instructor:''' Melissa Beers<br>		'''Lab Instructor:''' Melissa Beers<br>
	'''Lab Prep :''' Padma Kannabiran<br>		'''Lab Prep :''' Padma Kannabiran<br>
-	'''Study Group Leader/ Course Peer Mentor:''' <br><br>	+	'''Study Group Leader/ Course Peer Mentor:''' Christie Sze<br><br>

	'''Contact Info:'''<br>		'''Contact Info:'''<br>

Melissa Beers: /* BISC220 Lecture Schedule */

2010-01-21T17:43:41Z

BISC220 Lecture Schedule

←Older revision		Revision as of 17:43, 21 January 2010
Line 179:		Line 179:
	\| Ch. 15, p. 879-903 & 921-930 <br> CBI videos 15.4 & 15.5		\| Ch. 15, p. 879-903 & 921-930 <br> CBI videos 15.4 & 15.5
	\|-		\|-
		+	! 16
		+	\| F 4/2
		+	\| Cell Signaling II: GPCRs & Second Messengers <br><br> '''Workshop HW (#3) Due (10 pts)'''
		+	\| Ch. 15, p. 904-921; Ch. 8, p. 540-542 <br> CBI videos 15.3 & 15.6
		+	\|-
		+	! 17
		+	\| T 4/6
		+	\| Cytoskeleton I: Filament Structure, Dynamics & Regulation
		+	\| Ch. 16, p. 965-983, 987-988 & 992-1004 <br> CBI videos 16.1 & 16.3-16.5 <br><br>
		+	Rohn JL, Baum B (2010) Actin and cellular architecture at a glance. J Cell Science 123:155-158.*
		+	\|-
		+	!
		+	\| F 4/9
		+	\| '''EXAM II (100 pts)'''
		+	\|
		+	\|-
		+	! 18
		+	\| T 4/13
		+	\| Cytoskeleton II: Motor Proteins & Cell Movement
		+	\| Ch. 16, 1010-1022 & 1036-1046 <br> CBI videos 16.2 & 16.6-16.10
		+	\|-
		+	! 19
		+	\| F 4/16
		+	\| Cellular Reproduction I: The Cell Cycle & Cyclin Dependent Kinases
		+	\| Ch. 17, p. 1053-1066 <br> CBI video 17.1 <br> Lodish Ch. 20, p. 851-862 (on reserve)
		+	\|-
		+	! 20
		+	\| T 4/20
		+	\| Cellular Reproduction II: Mechanics of S Phase & Mitosis <br><br> '''Cytoskeleton Homework (#4) Due (10 points)'''
		+	\| Ch. 14, p. 1067—1090 <br> CBI videos 17.3-17.7
		+	\|-
		+	! 21
		+	\| F 4/23
		+	\| Cellular Reproduction III: Checkpoints & Control of Cell Division
		+	\| Ch. 17, p. 1061, 1088 & 1101-1110 <br> CBI video 17.2 <br><br>
		+	May KM, Hardwick KG (2006) The spindle checkpoint. J Cell Science 119:4139-4142.*
		+	\|-
		+	! 22
		+	\| T 4/27
		+	\| Apoptosis: Programmed Cell Death
		+	\| Ch. 18 <br> CBI video 18.1 <br><br>
		+	http://www.nature.com/milestones/development/milestones/full/milestone15.html
		+	\|-
		+	! 23
		+	\| F 4/30
		+	\| Cancer I: Features of Cancer Cells/Oncogenes & Tumor Suppressors <br><br> '''Cell Cycle Homework (#5) Due (10 points)'''
		+	\| Ch. 20, p. 1205-1240 <br> CBI videos 20.1, 20.2
		+	\|-
		+	! 24
		+	\| T 5/4
		+	\| Cancer II: Molecular Basis of Cancer & Novel Therapies
		+	\| Ch. 20, p. 1241-1265
		+	\|-
		+	\|}
		+	<br>
		+	‡ All readings are in the Alberts text unless otherwise noted. The starred (*) articles are available as electronic links or PDF documents on the E-Reserve sub-conference of the course FirstClass conference. The electronic version of this syllabus that is posted to the “Lecture Material” sub-conference of the course conference contains hyperlinks to the web resources listed as Readings.

Melissa Beers at 17:34, 21 January 2010

2010-01-21T17:34:28Z

←Older revision		Revision as of 17:34, 21 January 2010
Line 108:		Line 108:
	! 6		! 6
	\| F 2/12		\| F 2/12
		+	\| The Life Cycle of a Protein: Folding to Destruction
		+	\| Ch. 6 p. 387-399<br><br>
		+	Kolata G (1986) New Rule Proposed for Protein Degradation. Science 234:151-152.*<br><br>
		+	Bachmir A, Finley D, Varshavsky A (1986) In vivo half-life of a protein is a function of its amino-terminal residue. Nature 234:179-186.*<br><br>
		+	Wolf DH, Sommer T, Hilt W (2004) Death gives birth to life: the essential role of the ubiquitin-proteasome system in biology. Biochim Biophys Acta 1695:1-2.*
		+	\|-
		+	!
		+	\| T 2/16
		+	\|''' No Class—Monday Schedule'''
	\|		\|
		+	\|-
		+	! 7
		+	\| F 2/19
		+	\| Imaging Cells & Molecules <br><br> '''BLAST Homework (#1) Due (10 pts)'''
		+	\| Ch. 9 <br><br>
		+	http://bioeducate.ascb.org/ — check out 2008 ASCB “Celldance” Contest winning videos
		+	\|-
		+	! 8
		+	\| T 2/23
		+	\| Membranes & Membrane Proteins
		+	\| Ch. 10 <br><br> CBI videos 10.1-10.6
		+	\|-
		+	!
		+	\| F 2/26
		+	\| '''EXAM I (100 pts)'''
		+	\|
		+	\|-
		+	! 9
		+	\| T 3/2
		+	\| Membrane Transport & Electrical Properties of Membranes
		+	\| Ch. 11 p. 651-683 <br> CBI videos 11.1-11.6 & 15.1<br><br>
		+	Doyle DA et al. (1998) The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity. Science 280:69-77.*
		+	\|-
		+	! 10
		+	\| F 3/5
		+	\| Protein Sorting: Principles & Experimental Approaches <br><br> Protein Insertion into the Endoplasmic Reticulum
		+	\| Ch. 12 p. 695-704 & 723-738 <br> CBI videos 12.1, 12.4, & 12.6
		+	\|-
		+	! 11
		+	\| T 3/9
		+	\| ER Quality Control & Principles of Vesicle Trafficking
		+	\| Ch. 12, p. 738-742 <br> Ch. 13, p. 749-766 <br> CBI videos 13.1 & 13.4 <br><br>
		+	Pucadyil TJ, Schmid S (2009) Conserved Functions of Membrane Active GTPases in Coated Vesicle Formation. Science 325:1217-1220.*
		+	\|-
		+	! 12
		+	\| F 3/12
		+	\| Intra- and Trans-Cellular Vesicle Trafficking <br><br> I'''on Channel Homework (#2) Due (10 pts)'''
		+	\| Ch. 13, p. 766-809 <br> CBI videos 13.2, 13.3, 13.5 & 13.6
		+	\|-
		+	! 13
		+	\| T 3/16
		+	\| Nucleocytoplasmic Transport
		+	\| Ch. 12, p. 704-710 <br> CBI videos 12.2 & 12.5 <br><br>
		+	Weis K (2007) The Nuclear Pore Complex: Oily Spaghetti or Gummy Bear? Cell 130:405-407.*
		+	\|-
		+	! 14
		+	\| F 3/19
		+	\| '''Workshop:''' Nuclear Transport in STAT1 Transcription Factor Function
		+	\| McBride KM, Banninger G, McDonald C, Reich, NC (2002) Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-α. EMBO J. 21:1754-1763.* <br><br>
		+	McBride KM, Reich NC (2003) The ins and outs of STAT1 nuclear transport. Sci STKE 195:RE13*
		+	\|-
		+	!
		+	\| 3/23 & 3/26
		+	\| '''SPRING BREAK'''
		+	\|
		+	\|-
		+	! 15
		+	\| T 3/30
		+	\| Cell Signaling I: Overview/ RTKs & Ras-MAPK Pathway
		+	\| Ch. 15, p. 879-903 & 921-930 <br> CBI videos 15.4 & 15.5
		+	\|-

Melissa Beers: /* BISC220 Lecture Schedule */

2010-01-21T17:22:50Z

BISC220 Lecture Schedule

Melissa Beers: /* BISC220 Lecture Schedule */

2010-01-21T17:20:55Z

BISC220 Lecture Schedule

←Older revision		Revision as of 17:20, 21 January 2010
Line 75:		Line 75:
	! Lec. # !! Date !! Topics !! Reading		! Lec. # !! Date !! Topics !! Reading
	\|-		\|-
		+	! 1
		+	\| T 1/26
		+	\| Intro: The AMAZING World of the Cell <br> Protein Structure
		+	\| Review Ch. 1 & Ch. 2 (general background, review from BISC 110) <br> Ch. 3, p. 125-148 <br>
		+	Ch. 8, p. 527-530 (protein structure determination)<br>
		+	http://www.youtube.com/watch?v=BtZEqQ1cpmk (Harvard BioVisions)<br>
		+	View Cell Biology Interactive (CBI) videos 3.1-3.6, 3.9 (DVD that came with your textbook—see conference for access notes)
		+	\|-
		+	! 2
		+	\| F 1/29
		+	\| Protein Regulation & Social Context <br> Enzymes I: Mechanism of Catalysis
		+	\| Ch. 2, p. 72-81 <br> Ch. 3, p. 152-161, 164-167 & 175-190<br>
		+	CBI videos 3.7, 3.8 & 3.11 <br> Ringe D, Petsko G A (2008) How enzymes work. Science 320:1428-1429.*
		+	\|-
		+	! 3
		+	\| T 2/2
		+	\| Enzymes II: Kinetics & Regulation <br> '''Quiz: Amino Acids (10 pts)'''
		+	\| Ch. 3 p. 162-163 & 166-174 <br> CBI video 3.10 <br>
		+	Biology Hypertextbook Enzyme Biochemistry http://www.sciencegateway.org/resources/biologytext/index.html sections 3 & 4 (also try practice problems #1-3)
		+	\|-
		+	! 4
		+	\| F 2/5
		+	\| Protein Methods I: Protein Separation & Antibody Detection
		+	\| Ch. 8, p. 508-509 & 517-522 <br> Ch. 25, p. 1551-1561 (on the textbook DVD) <br> CBI video 25.2
		+	\|-
		+	! 5
		+	\| T 2/9
		+	\| Protein Methods II: Protein Purification & Functional Analysis
		+	\| Ch. 8, p. 510-516, 522-531 & 564-576 <br>
		+	Snyder M and Gallagher JEG (2009) Systems biology from a yeast omics perspective. FEBS Letters 583:3895-3899.*

Melissa Beers: /* BISC220 Cell Physiology */

2010-01-21T17:14:56Z

BISC220 Cell Physiology

←Older revision		Revision as of 17:14, 21 January 2010
Line 69:		Line 69:

	'''Please let your instructors know if you are having trouble during the semester. The sooner you bring a problem to our attention, the sooner we can help you address it.'''		'''Please let your instructors know if you are having trouble during the semester. The sooner you bring a problem to our attention, the sooner we can help you address it.'''
		+
		+	== BISC220 Lecture Schedule ==
		+	{\| border="1"
		+	\|+
		+	! Lec. # !! Date !! Topics !! Reading
		+	\|-

Melissa Beers: /* BISC220 Cell Physiology */

2010-01-21T17:12:57Z

BISC220 Cell Physiology

←Older revision		Revision as of 17:12, 21 January 2010
Line 53:		Line 53:
	\|-		\|-
	\|}		\|}
-	''POLICY ON LATE ASSIGNMENTS AND MAKE-UP EXAMS:''<br>	+	<br>
		+	'''POLICY ON LATE ASSIGNMENTS AND MAKE-UP EXAMS:'''<br>
	Make-up exams and quizzes will only be given in the case of a serious personal illness or family emergency that '''has been documented by your class dean'''. Similarly, excused extensions for lab reports or homework will not be granted except in the cases described. In such situations, if at all possible, the instructor should be notified '''prior''' to the class period in which the exam or quiz is to be administered or when the assignment is due. '''Unexcused late work will be penalized 5% per day and will not receive credit more than one week after the due date'''. Students who have a legitimate conflict with a scheduled exam are requested to speak with the instructor as soon as possible about taking the exam '''early''', but no more than 48 hours in advanced of the scheduled exam.		Make-up exams and quizzes will only be given in the case of a serious personal illness or family emergency that '''has been documented by your class dean'''. Similarly, excused extensions for lab reports or homework will not be granted except in the cases described. In such situations, if at all possible, the instructor should be notified '''prior''' to the class period in which the exam or quiz is to be administered or when the assignment is due. '''Unexcused late work will be penalized 5% per day and will not receive credit more than one week after the due date'''. Students who have a legitimate conflict with a scheduled exam are requested to speak with the instructor as soon as possible about taking the exam '''early''', but no more than 48 hours in advanced of the scheduled exam.
	<br><br>		<br><br>

Melissa Beers: /* BISC220 Cell Physiology */

2010-01-21T17:12:19Z

BISC220 Cell Physiology

←Older revision		Revision as of 17:12, 21 January 2010
Line 53:		Line 53:
	\|-		\|-
	\|}		\|}
		+	''POLICY ON LATE ASSIGNMENTS AND MAKE-UP EXAMS:''<br>
		+	Make-up exams and quizzes will only be given in the case of a serious personal illness or family emergency that '''has been documented by your class dean'''. Similarly, excused extensions for lab reports or homework will not be granted except in the cases described. In such situations, if at all possible, the instructor should be notified '''prior''' to the class period in which the exam or quiz is to be administered or when the assignment is due. '''Unexcused late work will be penalized 5% per day and will not receive credit more than one week after the due date'''. Students who have a legitimate conflict with a scheduled exam are requested to speak with the instructor as soon as possible about taking the exam '''early''', but no more than 48 hours in advanced of the scheduled exam.
		+	<br><br>
		+
		+	'''STUDENTS WITH SPECIAL NEEDS: ''' <br>
		+	Students entitled to disability-related accommodations are requested to speak with the instructor about their needs well in advance of scheduled quizzes, exams, and assignment due dates.<br><br>
		+
		+	'''POLICY ON COLLABORATION: ''' <br>
		+	Working in groups with your classmates is encouraged as a valuable way to enhance your understanding of the course material; however, the actual writing of all assignments, including homework and lab reports, must be completed individually.<br><br>
		+
		+	'''POTENTIAL CHANGES TO THE SYLLABUS: ''' <br>
		+	The instructor reserves the right to modify the syllabus during the semester as she deems necessary to meet the course goals in a reasonable manner.<br><br>
		+
		+
		+	'''Please let your instructors know if you are having trouble during the semester. The sooner you bring a problem to our attention, the sooner we can help you address it.'''

Melissa Beers: /* BISC220 Cell Physiology */

2010-01-21T17:09:59Z

BISC220 Cell Physiology

←Older revision		Revision as of 17:09, 21 January 2010
Line 38:		Line 38:
	! Assessment !! Points		! Assessment !! Points
	\|-		\|-
-	! Hour Exams \| 200 points	+	! Hour Exams
		+	\| 200 points
	\|-		\|-
-	! Final Exam \| 140 points	+	! Final Exam
		+	\| 140 points
	\|-		\|-
-	! Homework/Quizzes \| 60 points	+	! Homework/Quizzes
		+	\| 60 points
	\|-		\|-
-	! Laboratory \| 200 points	+	! Laboratory
		+	\| 200 points
	\|-		\|-
	! Total !! 600 points		! Total !! 600 points
	\|-		\|-
	\|}		\|}

←Older revision		Revision as of 17:22, 21 January 2010
Line 77:		Line 77:
	! 1		! 1
	\| T 1/26		\| T 1/26
-	\| Intro: The AMAZING World of the Cell <br> Protein Structure	+	\| Intro: The AMAZING World of the Cell <br><br> Protein Structure
	\| Review Ch. 1 & Ch. 2 (general background, review from BISC 110) <br> Ch. 3, p. 125-148 <br>		\| Review Ch. 1 & Ch. 2 (general background, review from BISC 110) <br> Ch. 3, p. 125-148 <br>
	Ch. 8, p. 527-530 (protein structure determination)<br>		Ch. 8, p. 527-530 (protein structure determination)<br>
-	http://www.youtube.com/watch?v=BtZEqQ1cpmk (Harvard BioVisions)<br>	+	http://www.youtube.com/watch?v=BtZEqQ1cpmk (Harvard BioVisions)<br><br>
	View Cell Biology Interactive (CBI) videos 3.1-3.6, 3.9 (DVD that came with your textbook—see conference for access notes)		View Cell Biology Interactive (CBI) videos 3.1-3.6, 3.9 (DVD that came with your textbook—see conference for access notes)
	\|-		\|-
	! 2		! 2
	\| F 1/29		\| F 1/29
-	\| Protein Regulation & Social Context <br> Enzymes I: Mechanism of Catalysis	+	\| Protein Regulation & Social Context <br><br> Enzymes I: Mechanism of Catalysis
	\| Ch. 2, p. 72-81 <br> Ch. 3, p. 152-161, 164-167 & 175-190<br>		\| Ch. 2, p. 72-81 <br> Ch. 3, p. 152-161, 164-167 & 175-190<br>
-	CBI videos 3.7, 3.8 & 3.11 <br> Ringe D, Petsko G A (2008) How enzymes work. Science 320:1428-1429.*	+	CBI videos 3.7, 3.8 & 3.11 <br> <br>Ringe D, Petsko G A (2008) How enzymes work. Science 320:1428-1429.*
	\|-		\|-
	! 3		! 3
	\| T 2/2		\| T 2/2
-	\| Enzymes II: Kinetics & Regulation <br> '''Quiz: Amino Acids (10 pts)'''	+	\| Enzymes II: Kinetics & Regulation <br><br> '''Quiz: Amino Acids (10 pts)'''
	\| Ch. 3 p. 162-163 & 166-174 <br> CBI video 3.10 <br>		\| Ch. 3 p. 162-163 & 166-174 <br> CBI video 3.10 <br>
	Biology Hypertextbook Enzyme Biochemistry http://www.sciencegateway.org/resources/biologytext/index.html sections 3 & 4 (also try practice problems #1-3)		Biology Hypertextbook Enzyme Biochemistry http://www.sciencegateway.org/resources/biologytext/index.html sections 3 & 4 (also try practice problems #1-3)
Line 103:		Line 103:
	\| T 2/9		\| T 2/9
	\| Protein Methods II: Protein Purification & Functional Analysis		\| Protein Methods II: Protein Purification & Functional Analysis
-	\| Ch. 8, p. 510-516, 522-531 & 564-576 <br>	+	\| Ch. 8, p. 510-516, 522-531 & 564-576 <br><br>
	Snyder M and Gallagher JEG (2009) Systems biology from a yeast omics perspective. FEBS Letters 583:3895-3899.*		Snyder M and Gallagher JEG (2009) Systems biology from a yeast omics perspective. FEBS Letters 583:3895-3899.*
		+	\|-
		+	! 6
		+	\| F 2/12
		+	\|