BMCB625:DNA Replication

(Homework) Questions

Larry

Lopes et al

1. What observations lead to the authors' suggestion that discontinuites left randomly behind the fork are not immediately sealed after the passage of the replication fork? Larry's Question Page

Heller and Marians

1. How did the author cleverly show that the same DnaB from the lagging strand was involved in leading strand reinitation? Larry's Question Page

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Chayne

Jon

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Chris

Lopes et al (UV-irrad of S. cerevisiae; EM grids and 2-D gel electrophoresis)

1. Lopes and colleagues never actually demonstrate that the ssDNA is located on the strand opposite the UV photoproducts. Suggest a possible way in which this may be elucidated.

Heller and Marians (Biochemical purification and modifications from E.coli and chemical Mods.)

1. More to come... :)

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Mahta

Jeremy

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