BMCB625:Exon Jxn Complex: Difference between revisions
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*of Interest (no label) | *of Interest (no label) | ||
* (o)(Ref 3, LeHir) A good overview on how introns may influence gene expression, and why the EJC (Exon Junction Complex) is such an important player in the "mRNA to translation steps" in the control of gene expression. | * (o)(Ref 3, LeHir) A good overview on how introns may influence gene expression, and why the EJC (Exon Junction Complex) is such an important player in the "mRNA to translation steps" in the control of gene expression. | ||
*(o)(Ref4) Great Review on EJC | *(o)(Ref4) Great Review on EJC, and a relatively quick read (five to ten minutes). | ||
<biblio> | <biblio> | ||
Revision as of 11:06, 30 May 2007
Papers
- Bono F, Ebert J, Lorentzen E, and Conti E. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Cell. 2006 Aug 25;126(4):713-25. DOI:10.1016/j.cell.2006.08.006 |
Bonus Materials
Ranking:
- Critical Read/of Outstanding Interest (oo)
- Importand Read (o)
- of Interest (no label)
- (o)(Ref 3, LeHir) A good overview on how introns may influence gene expression, and why the EJC (Exon Junction Complex) is such an important player in the "mRNA to translation steps" in the control of gene expression.
- (o)(Ref4) Great Review on EJC, and a relatively quick read (five to ten minutes).
- Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Séraphin B, Le Hir H, and Andersen GR. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science. 2006 Sep 29;313(5795):1968-72. DOI:10.1126/science.1131981 |
- Le Hir H, Nott A, and Moore MJ. How introns influence and enhance eukaryotic gene expression. Trends Biochem Sci. 2003 Apr;28(4):215-20. DOI:10.1016/S0968-0004(03)00052-5 |
- Tange TØ, Nott A, and Moore MJ. The ever-increasing complexities of the exon junction complex. Curr Opin Cell Biol. 2004 Jun;16(3):279-84. DOI:10.1016/j.ceb.2004.03.012 |
- Stroupe ME, Tange TØ, Thomas DR, Moore MJ, and Grigorieff N. The three-dimensional arcitecture of the EJC core. J Mol Biol. 2006 Jul 21;360(4):743-9. DOI:10.1016/j.jmb.2006.05.049 |
- Shibuya T, Tange TØ, Sonenberg N, and Moore MJ. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol. 2004 Apr;11(4):346-51. DOI:10.1038/nsmb750 |
- Ballut L, Marchadier B, Baguet A, Tomasetto C, Séraphin B, and Le Hir H. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol Biol. 2005 Oct;12(10):861-9. DOI:10.1038/nsmb990 |
- Shi H and Xu RM. Crystal structure of the Drosophila Mago nashi-Y14 complex. Genes Dev. 2003 Apr 15;17(8):971-6. DOI:10.1101/gad.260403 |
- Cordin O, Banroques J, Tanner NK, and Linder P. The DEAD-box protein family of RNA helicases. Gene. 2006 Feb 15;367:17-37. DOI:10.1016/j.gene.2005.10.019 |
Unresolved Questions for Followup
(Homework) Discussion Topics /Questions
Paper for additional Discussion (2 figures presented in EJC presentation on Thurs. 31 May 2007):
- Noble CG, Song H (2007) MLN51 Stimulates the RNA-Helicase Activity of eIF4AIII. PLoS ONE 2(3): e303. doi:10.1371/journal.pone.0000303[[1]]
- Can post a comment on PLos (Public Library of Science) for everyone in the world to discuss the positive aspects, as well as limitations of this paper.
