BME100 f2017:Group14 W0800 L3: Difference between revisions
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:::·20 total blood draws | :::·20 total blood draws | ||
::*Maximum amount of blood to draw per person: about 3% of their total blood volume | ::*Maximum amount of blood to draw per person: about 3% of their total blood volume | ||
::: | :::*On average, people have 5 liters<sup>3</sup> of blood so the average of blood allowed to draw is .15 liters<sup>1</sup> | ||
:::*It takes approximately .003 liters per blood draw to receive an accurate reading <sup>4</sup> | |||
:::*Take initial blood reading | |||
:::*Draw blood every minute for 5 minutes, then every 5 minutes for an hour | |||
:::*Draw blood once it has been 2 hours for every two hours until total time has reached 8 hours (this will show how long the drug lasts in the bloodstream) | |||
Factors to consider: The average ambulance response time is 6 minutes and 35 seconds, which means that someone who is having a seizure has to wait 6 minutes before paramedics even arrive on the scene to start an IV or other form of treatment.<sup>2</sup> | |||
:::* | |||
:::* | |||
:::* | |||
:::* | |||
=References= | =References= |
Revision as of 16:54, 20 September 2017
TEAM MEMBERS
Correlation Coefficient
Statistical Analysis
Graphs
Summary of Results
Design for Our Experiment
Gold Standards:
- ·Oral medication of Lorazepam
- ·IV Lorazepam
- ·Rectal Diazapam
Target sample size: 660, arrived at this number by calculating the current amount of people with epilepsy in the US (3 million) and the confidence level (5%)
To test how fast medication is getting into bloodstream:
- 1. Compare oral dosage of Lorazepam, IV injection of Lorazepam, rectal Diazepam, and our auto injector (LorazePen)
- 2. Obtain sample size (approximately 660 people)
- 500 people to be divided into three groups: one receiving IV, rectal, and auto injector (these people are epileptics, ranging from focal to generalized)
- 160 people will receive the oral dosage (these people are not actively seizing, rather they have been prescribed it for anxiety)
- 3. Set time intervals for which we will take blood samples to measure the concentration of medication inside the bloodstream
- Intervals (min): 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 120, 240, 360, 480
- ·20 total blood draws
- Maximum amount of blood to draw per person: about 3% of their total blood volume
- On average, people have 5 liters3 of blood so the average of blood allowed to draw is .15 liters1
- It takes approximately .003 liters per blood draw to receive an accurate reading 4
- Take initial blood reading
- Draw blood every minute for 5 minutes, then every 5 minutes for an hour
- Draw blood once it has been 2 hours for every two hours until total time has reached 8 hours (this will show how long the drug lasts in the bloodstream)
Factors to consider: The average ambulance response time is 6 minutes and 35 seconds, which means that someone who is having a seizure has to wait 6 minutes before paramedics even arrive on the scene to start an IV or other form of treatment.2