Basson

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== Signalling and morphogenesis ==
== Signalling and morphogenesis ==
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All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain.  The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures.  
All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain.  The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures.  
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The broad aim of our research is to understand how intracellular signalling regulators of the Sprouty family are employed to coordinate morphogenesis of the cerebellum and pharyngeal pouches.
The broad aim of our research is to understand how intracellular signalling regulators of the Sprouty family are employed to coordinate morphogenesis of the cerebellum and pharyngeal pouches.
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== Lab news ==
== Lab news ==
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Samantha Martin joined the lab recently as a new technical assistant.
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Welcome to Samantha Martin and Abi Jackson who recently joined the lab.
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Mohi Ahmed submitted his PhD thesis.
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Congratulations to Mohi Ahmed for submitting his PhD thesis.
== Recent publications ==
== Recent publications ==

Revision as of 14:13, 30 September 2008

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Contents

Welcome to the Basson lab at King's College London

Our research is aimed at understanding the signalling mechanisms that control morphogenesis of complex structures and organs in the developing embryo and newborn

Signalling and morphogenesis

All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain. The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures.

We are interested in the role intracellular regulators of specific signalling pathways play during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes.

The broad aim of our research is to understand how intracellular signalling regulators of the Sprouty family are employed to coordinate morphogenesis of the cerebellum and pharyngeal pouches.

Lab news

Welcome to Samantha Martin and Abi Jackson who recently joined the lab.

Congratulations to Mohi Ahmed for submitting his PhD thesis.

Recent publications

Basson, M.A., Echevarria, D., Peterson Ahn, C, Sudarov, A., Joyner, A.L., Mason, I.J., Martinez, S. & Martin, G.R. (2008) Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development. Development 135: 889-898.

Rozen, E.J., Schmidt, H., Dolcet, X., Basson, M.A., Jain, S. & Encinas, M. (2008) Loss of Sprouty1 rescues renal agenesis in Ret knockin mice lacking tyrosine 1062. J. Amer. Soc. Nephrol. In press.
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