Basson

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== Welcome to the Basson lab at King's College London ==
== Welcome to the Basson lab at King's College London ==
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'''Our research is aimed at understanding the signalling mechanisms that control morphogenesis of complex structures and organs in the developing embryo and newborn'''
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'''Our research is aimed at uncovering the signalling mechanisms that control morphogenesis of complex structures and organs in the developing embryo and newborn
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== Signalling and morphogenesis ==
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The Basson laboratory is located on the 27th floor of Guy's Hospital in the Department of Craniofacial and Stem Cell Biology and affiliated with the MRC Centre for Developmental Neurobiology on Guy's Campus [http://www.kcl.ac.uk/depsta/biomedical/mrc/index.php?page=http://www.kcl.ac.uk/depsta/biomedical/mrc/ResearchGroup.php?GroupID=18]'''
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All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain.  The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures.
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== FGF signalling in development and disease ==
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We are interested in the role intracellular regulators of specific signalling pathways play during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes.
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All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain.  The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures. We are interested in understanding how signalling centres are established in the embryo and how signalling pathways are regulated during development. Current research projects in the lab primarily focus on the fibroblast growth factor (FGF) signalling pathway and our aim is to understand how deregulated FGF signalling results in birth defects and cellular malfunction. We are particularly interested in elucidating the functions of the Sprouty genes, which encode FGF antagonists; Tbx1, a T-box transcription factor implicated in DiGeorge syndrome and Chd7, a chromatin remodeller, mutated in CHARGE syndrome.
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The broad aim of our research is to understand how intracellular signalling regulators of the Sprouty family are employed to coordinate morphogenesis of the cerebellum and pharyngeal pouches.
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== In the press ==
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== Lab news ==
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Our work on the cerebellum and autism features in a new article in International Innovation:
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Jenny Gardiner and Yuichiro Yaguchi presented their work at the Mammalian Genetics and Development Workshop at the ICH this month.
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== Recent publications ==
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[[Image:Basson_International_Innovation.pdf]]
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Basson, M.A., Echevarria, D., Peterson Ahn, C, Sudarov, A., Joyner, A.L., Mason, I.J., Martinez, S. & Martin, G.R. (2008) Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development. Development 135: 889-898.
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== Manuscripts in press ==
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Rozen, E.J., Schmidt, H., Dolcet, X., Basson, M.A., Jain, S. & Encinas, M. (2008) Loss of Sprouty1 rescues renal agenesis in Ret knockin mice lacking tyrosine 1062. J. Amer. Soc. Nephrol. In press.
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*Chakkalakal, J., Jones, K., Basson, M.A. & Brack, A.S. (2012) The aged niche disrupts muscle stem cell quiescence. '''Nature''' (in press).
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*Magnani, D., Amaniti, E-M., Benadiba, C., Hasenpusch-Theil, K., Yu, T., Basson, M.A., Price, D.J., Lebrand, C. & Theil, T. (2012) Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. '''Cerebral Cortex''' (in press).
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*Pitera, J.E., Woolf, A.S., Basson, M.A. & Scambler, P.J. (2012) Sprouty1 haploinsufficiency permits kidney maturation in Fraser syndrome renal agenesis mice. '''J. Am. Soc. Nephrol.''' (in press).
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== Publications in press ==

Revision as of 10:13, 19 September 2012

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Contents

Welcome to the Basson lab at King's College London

Our research is aimed at uncovering the signalling mechanisms that control morphogenesis of complex structures and organs in the developing embryo and newborn

The Basson laboratory is located on the 27th floor of Guy's Hospital in the Department of Craniofacial and Stem Cell Biology and affiliated with the MRC Centre for Developmental Neurobiology on Guy's Campus [1]

FGF signalling in development and disease

All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain. The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures. We are interested in understanding how signalling centres are established in the embryo and how signalling pathways are regulated during development. Current research projects in the lab primarily focus on the fibroblast growth factor (FGF) signalling pathway and our aim is to understand how deregulated FGF signalling results in birth defects and cellular malfunction. We are particularly interested in elucidating the functions of the Sprouty genes, which encode FGF antagonists; Tbx1, a T-box transcription factor implicated in DiGeorge syndrome and Chd7, a chromatin remodeller, mutated in CHARGE syndrome.

In the press

Our work on the cerebellum and autism features in a new article in International Innovation:

Image:Basson International Innovation.pdf

Manuscripts in press

  • Chakkalakal, J., Jones, K., Basson, M.A. & Brack, A.S. (2012) The aged niche disrupts muscle stem cell quiescence. Nature (in press).
  • Magnani, D., Amaniti, E-M., Benadiba, C., Hasenpusch-Theil, K., Yu, T., Basson, M.A., Price, D.J., Lebrand, C. & Theil, T. (2012) Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. Cerebral Cortex (in press).
  • Pitera, J.E., Woolf, A.S., Basson, M.A. & Scambler, P.J. (2012) Sprouty1 haploinsufficiency permits kidney maturation in Fraser syndrome renal agenesis mice. J. Am. Soc. Nephrol. (in press).
== Publications in press ==
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