Basson

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Contents

Welcome to the Basson lab at King's College London

Our research is aimed at understanding the signalling mechanisms that control morphogenesis of complex structures and organs in the developing embryo and newborn

Signalling and morphogenesis

All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain. The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures.

We are interested in the role intracellular regulators of specific signalling pathways play during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes.

The broad aim of our research is to understand how intracellular signalling regulators of the Sprouty family are employed to coordinate organogenesis. Recent observations suggest that these genes may also play key roles in controlling organ and tissue maintenance by regulating MAPK signalling in fibroblasts and stem cells.

News

Our lab is now affiliated with the MRC Centre for Developmental Neurobiology [1]

Publications in press

Yaguchi, Y., Yu, T., Ahmed, M.U., Berry, M., Mason, I. & Basson, M.A. (2009) FGF gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development. Dev. Dyn. in press

Calmont, A., Ivins, S., Lammerts Van Bueren, K., Papangeli, I., Kyriakopoulou, V., Andrews, W.D., Martin, J.F., Moon, A.M., Illingworth, E.A., Basson, M.A. & Scambler, P.J. (2009) Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development in press.

Randall, V., McCue, K., Roberts, C., Kyriakopoulou, V., Beddow, S., Vitelli, F., Prescott, K., Shaw-Smith, C., Devriendt, K., Bosman, E., Steffes, G., Steel, K., Simrick, S., Basson, M.A., Illingworth, E. & Scambler, P. (2009) Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm. J. Clin. Invest. in press
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