Basson

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Contents

Welcome to the Basson lab at King's College London

Our research is aimed at understanding the signalling mechanisms that control morphogenesis of complex structures and organs in the developing embryo and newborn

FGF signalling in development and disease

All organs in the body originate from relatively simple structures in the embryo. For example a simple epithelial tube, the neural tube, develops into the highly complex brain. The many forces and growth factors that act upon embryonic tissues are precisely coordinated to shape the morphogenesis of more complex structures. We are interested in understanding how signalling centres are established in the embryo and how signalling pathways are regulated during development. Current research projects in the lab primarily focus on the fibroblast growth factor (FGF) signalling pathway and our aim is to elucidate how deregulated FGF signalling results in birth defects and cellular malfunction. We are particulalrly interested in understanding the functions of the Sprouty genes, which encode FGF antagonists, Tbx1, a T-box transcription factor implicated in DiGeorge syndrome and Chd7, a chromatin remodeller, mutated in CHARGE syndrome. We are studying the role of these genes in the development of the pharyngeal apparatus and the cerebellum and the biology of adult stem cells.

News

Our lab is now affiliated with the MRC Centre for Developmental Neurobiology [1]

Click on the link at the top of the page for our provisional programme for this year's KCL Mouse Genetics Club.

Publications in press

Shea, K.L., Xiang, W., LaPorta, V.S., Licht, J.D., Keller, C., Basson, M.A. & Brack, A.S. (2010) Sprouty1 regulates self-renewal of the adult muscle stem cell pool during regeneration. Cell Stem Cell in press.
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