Basson:Research - Revision history

Mikeyab68: /* Adult stem cell biology */

2011-12-10T16:36:25Z

Adult stem cell biology

←Older revision		Revision as of 16:36, 10 December 2011
Line 27:		Line 27:
	'''Research team: Abigail Jackson'''		'''Research team: Abigail Jackson'''
	----		----
-
-
-
-	~~== Adult stem cell biology ==~~
-
-	We recently showed, in collaboration with the Brack lab at Harvard, that Sprouty1 plays an important role in adult muscle stem cells or "satellite cells". This work is continuing in collaboration with the Brack lab. In addition, we are investigating the role of Spry1 in adult neural stem cells in the adult brain.
-
-	~~'''Research team: Kieran Jones, Tian Yu'''~~

Mikeyab68: /* Chromatin remodelling and brain development */

2011-12-10T16:36:07Z

Chromatin remodelling and brain development

←Older revision		Revision as of 16:36, 10 December 2011
Line 28:		Line 28:
	----		----

-	~~== Chromatin remodelling and brain development ==~~

-	Patients affected by CHARGE syndrome suffer from a number of brain defects, including autism spectrum disorders, learning difficulties and cerebellar hypoplasia. We are using mouse models for this syndrome in which the Chd7 gene is mutated to elucidate the function of CHD7 in brain development.
-
-	~~'''Research team: Tian Yu, Katrin Danielsen, Eugenia Sanz Smachetti'''~~

	== Adult stem cell biology ==		== Adult stem cell biology ==

Mikeyab68: /* Signalling and morphogenesis */

2011-12-10T16:34:56Z

Signalling and morphogenesis

←Older revision		Revision as of 16:34, 10 December 2011
Line 1:		Line 1:
	{{Template:Basson}}		{{Template:Basson}}
-	== Signalling and ~~morphogenesis~~ ==	+	== Fine-tuning Signalling and gene expression levels ==


-	The precise coordination of the many forces and growth factors acting upon embryonic tissues is required for the development of complex organs. We are interested in how intracellular signalling pathways are regulated during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies in a number of biological systems have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes. Recent evidence indicate that chromatin remodelling factors fine-tunes gene expression levels during development. We are interested in ~~inderstanding~~ the various functions of the CHD7 chromatin remodelling factor in brain development.	+	The precise coordination of the many forces and growth factors acting upon embryonic tissues is required for the development of complex organs. We are interested in how intracellular signalling pathways are regulated during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies in a number of biological systems have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes. Recent evidence indicate that chromatin remodelling factors fine-tunes gene expression levels during development. We are interested in understanding the various functions of the CHD7 chromatin remodelling factor in brain development.
-		+

Mikeyab68: /* Signalling and morphogenesis */

2011-12-10T16:32:52Z

Signalling and morphogenesis

←Older revision		Revision as of 16:32, 10 December 2011
Line 3:		Line 3:


-	The precise coordination of the many forces and growth factors acting upon embryonic tissues is required for the development of complex organs. We are interested in how intracellular signalling pathways are regulated during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies in a number of biological systems have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes.	+	The precise coordination of the many forces and growth factors acting upon embryonic tissues is required for the development of complex organs. We are interested in how intracellular signalling pathways are regulated during organogenesis. Many cell surface receptors use reversible tyrosine phosphorylation as a means of signal transduction. Studies in a number of biological systems have suggested that these signalling pathways are not merely ON/OFF switches but that subtle differences in signal strength and duration often result in profoundly different outcomes. Recent evidence indicate that chromatin remodelling factors fine-tunes gene expression levels during development. We are interested in inderstanding the various functions of the CHD7 chromatin remodelling factor in brain development.

-	The broad aim of our research is to understand how intracellular signaling regulators of the Sprouty family are employed to coordinate morphogenesis of the cerebellum and pharyngeal pouches and how deregulated signalling leads to disease.


	----		----
-	'''Cerebellar morphogenesis:''' The cerebellum is the brain’s control centre for motor coordination and defects in cerebellar development are often associated with ataxia or medulloblastoma, the most common type of childhood cancer. We are interested in how the cerebellum is constructed during embryonic and early postnatal development. ~~Studies on conditional mid-hindbrain-specific Sprouty mutants have shown that these genes play important roles during postnatal cerebellar morphogenesis and we~~ are investigating this process using ~~inducible,~~ conditional gene inactivation approaches in vivo.	+	'''Cerebellar morphogenesis:''' The cerebellum is the brain’s control centre for motor coordination and defects in cerebellar development are often associated with ataxia or medulloblastoma, the most common type of childhood cancer. We are interested in how the cerebellum is constructed during embryonic and early postnatal development. We are investigating this process using conditional gene inactivation approaches in vivo.

	'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''		'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''

-	'''~~Research team~~: Tian Yu~~, Yuichiro Yaguchi~~'''	+	'''Researcher: Tian Yu'''

		+	----
		+	'''Adult stem cell function:''' Both regulators of intracellular signalling (e.g. Spry1) and chromatin remodelling factors are important for normal adult stem cell function. We are investigating the roles of these factors in adult stem cells in the muscle (in collaboration with Dr. Andrew Brack (Harvard) and brain.
		+
		+	'''Supported by the BBSRC'''
		+
		+	'''Researcher: Kieran Jones'''

	----		----
-	'''Thymus organogenesis, pharyngeal pouch patterning and DiGeorge syndrome:''' Our recent experiments have indicated that several essential organs such as the thymus, parathyroid, middle ear and cranial sensory ganglia that develop wholly or in part from the pharyngeal apparatus exhibit multiple defects in Sprouty mutant mice. These same organs are affected in 22q11 deletion or DiGeorge syndrome and we are investigating the molecular and developmental basis of these defects in mouse embryos.'''	+	'''Thymus organogenesis, pharyngeal pouch patterning and DiGeorge syndrome:''' Our recent experiments have indicated that several essential organs such as the thymus, parathyroid, middle ear and cranial sensory ganglia that develop wholly or in part from the pharyngeal apparatus exhibit multiple defects in Sprouty mutant mice. These same organs are affected in 22q11 deletion or DiGeorge syndrome and we are investigating the molecular and developmental basis of these defects in mouse embryos. A current interest is the function of and interaction between Tbx1 and FGF signalling in the pharyngeal endoderm during pharyngeal pouch morphogenesis'''

	'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''		'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''

-	'''Research team: ~~Subreena Simrick, Jenny Gardiner,~~ Abigail Jackson'''	+	'''Research team: Abigail Jackson'''
	----		----

Mikeyab68: /* Adult stem cell biology */

2011-01-01T18:35:28Z

Adult stem cell biology

←Older revision		Revision as of 18:35, 1 January 2011
Line 33:		Line 33:

	We recently showed, in collaboration with the Brack lab at Harvard, that Sprouty1 plays an important role in adult muscle stem cells or "satellite cells". This work is continuing in collaboration with the Brack lab. In addition, we are investigating the role of Spry1 in adult neural stem cells in the adult brain.		We recently showed, in collaboration with the Brack lab at Harvard, that Sprouty1 plays an important role in adult muscle stem cells or "satellite cells". This work is continuing in collaboration with the Brack lab. In addition, we are investigating the role of Spry1 in adult neural stem cells in the adult brain.
		+
		+	'''Research team: Kieran Jones, Tian Yu'''

Mikeyab68: /* Chromatin remodelling and brain development */

2011-01-01T18:34:50Z

Chromatin remodelling and brain development

←Older revision		Revision as of 18:34, 1 January 2011
Line 28:		Line 28:
	Patients affected by CHARGE syndrome suffer from a number of brain defects, including autism spectrum disorders, learning difficulties and cerebellar hypoplasia. We are using mouse models for this syndrome in which the Chd7 gene is mutated to elucidate the function of CHD7 in brain development.		Patients affected by CHARGE syndrome suffer from a number of brain defects, including autism spectrum disorders, learning difficulties and cerebellar hypoplasia. We are using mouse models for this syndrome in which the Chd7 gene is mutated to elucidate the function of CHD7 in brain development.

-	'''Research team: Tian Yu, Katrin Danielsen, Eugenia Sanz ~~Schmachetti~~'''	+	'''Research team: Tian Yu, Katrin Danielsen, Eugenia Sanz Smachetti'''

	== Adult stem cell biology ==		== Adult stem cell biology ==

	We recently showed, in collaboration with the Brack lab at Harvard, that Sprouty1 plays an important role in adult muscle stem cells or "satellite cells". This work is continuing in collaboration with the Brack lab. In addition, we are investigating the role of Spry1 in adult neural stem cells in the adult brain.		We recently showed, in collaboration with the Brack lab at Harvard, that Sprouty1 plays an important role in adult muscle stem cells or "satellite cells". This work is continuing in collaboration with the Brack lab. In addition, we are investigating the role of Spry1 in adult neural stem cells in the adult brain.

Mikeyab68: /* Chromatin remodelling and brain development */

2011-01-01T18:33:49Z

Chromatin remodelling and brain development

←Older revision		Revision as of 18:33, 1 January 2011
Line 27:		Line 27:

	Patients affected by CHARGE syndrome suffer from a number of brain defects, including autism spectrum disorders, learning difficulties and cerebellar hypoplasia. We are using mouse models for this syndrome in which the Chd7 gene is mutated to elucidate the function of CHD7 in brain development.		Patients affected by CHARGE syndrome suffer from a number of brain defects, including autism spectrum disorders, learning difficulties and cerebellar hypoplasia. We are using mouse models for this syndrome in which the Chd7 gene is mutated to elucidate the function of CHD7 in brain development.
		+
		+	'''Research team: Tian Yu, Katrin Danielsen, Eugenia Sanz Schmachetti'''

	== Adult stem cell biology ==		== Adult stem cell biology ==

	We recently showed, in collaboration with the Brack lab at Harvard, that Sprouty1 plays an important role in adult muscle stem cells or "satellite cells". This work is continuing in collaboration with the Brack lab. In addition, we are investigating the role of Spry1 in adult neural stem cells in the adult brain.		We recently showed, in collaboration with the Brack lab at Harvard, that Sprouty1 plays an important role in adult muscle stem cells or "satellite cells". This work is continuing in collaboration with the Brack lab. In addition, we are investigating the role of Spry1 in adult neural stem cells in the adult brain.

Mikeyab68: /* Signalling and morphogenesis */

2011-01-01T18:32:42Z

Signalling and morphogenesis

←Older revision		Revision as of 18:32, 1 January 2011
Line 13:		Line 13:
	'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''		'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''

-	'''Tian Yu, Yuichiro Yaguchi'''	+	'''Research team: Tian Yu, Yuichiro Yaguchi'''


Line 21:		Line 21:
	'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''		'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''

-	'''Subreena Simrick, Jenny Gardiner, Abigail Jackson'''	+	'''Research team: Subreena Simrick, Jenny Gardiner, Abigail Jackson'''
	----		----

Mikeyab68: /* Signalling and morphogenesis */

2011-01-01T18:32:13Z

Signalling and morphogenesis

←Older revision		Revision as of 18:32, 1 January 2011
Line 12:		Line 12:

	'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''		'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''
		+
	'''Tian Yu, Yuichiro Yaguchi'''		'''Tian Yu, Yuichiro Yaguchi'''

Line 19:		Line 20:

	'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''		'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''
		+
	'''Subreena Simrick, Jenny Gardiner, Abigail Jackson'''		'''Subreena Simrick, Jenny Gardiner, Abigail Jackson'''
	----		----

Mikeyab68: /* Signalling and morphogenesis */

2011-01-01T18:31:51Z

Signalling and morphogenesis

←Older revision		Revision as of 18:31, 1 January 2011
Line 12:		Line 12:

	'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''		'''Supported by the [http://www.wellcome.ac.uk/ Wellcome Trust]'''
		+	'''Tian Yu, Yuichiro Yaguchi'''


Line 18:		Line 19:

	'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''		'''Supported by the [http://www.mrc.ac.uk/index.htm Medical Research Council]'''
		+	'''Subreena Simrick, Jenny Gardiner, Abigail Jackson'''
	----		----