Berglund:Focus

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We are an RNA lab involved in studying RNA/Protein interactions as well as RNA/Au interactions.
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please see:<br>
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http://chemistry.uoregon.edu/fac.html?berglund
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We have two major goals.
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1)  Understanding splicing of RNA. 
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One aspect is to study various proteins involved in the splicing of the 5' or 3'end of introns and looking at the mechanisms involved in<br>
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binding and recognition. We use footprinting, GST-pulldowns, binding gels, in vitro and in vivo splicing, northerns, westerns and x-ray<br> crystallography in order to achieve our goals.<br><br>
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Another aspect is to study particular proteins involved in disease associated with alternative splicing.  In particular we study MBNL that <br>is involved in myotonic dystrophy.  We also study particular genetic sequences believed to be involved in alternative or disease related <br>splicing.  As a side project we are investigating competitive binders to CUG repeats to block MBNL from binding.<br><br>
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A third aspect is that we do computational analysis of entire genomes of particular species looking for conservation of sequence<br> elements within introns associated with both constitutive and alternative splicing.  Information from these analyses can be used to study both <br>in vivo and in vitro effects of these splicing elements.<br><br>
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2)  Nanoparticles
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We have teamed up with a material sciences group here at the University of Oregon to study the production of specificially shaped <br>and sized gold nanoparticles using RNA as the reaction driver/director.
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Current revision

please see:
http://chemistry.uoregon.edu/fac.html?berglund

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