BioControl:Week2: Difference between revisions
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** Sensors: this seems pretty straightforward - there are lots of examples of molecules that bind to other molecules and "sense" the presence of those molecules. However the "signal" out of the sensor is less obvious. Sometimes you get a conformation change that enables the molecule to do something new and different. Sometimes you block an event from occuring and that is the "signal" corresponding to that sensor. | ** Sensors: this seems pretty straightforward - there are lots of examples of molecules that bind to other molecules and "sense" the presence of those molecules. However the "signal" out of the sensor is less obvious. Sometimes you get a conformation change that enables the molecule to do something new and different. Sometimes you block an event from occuring and that is the "signal" corresponding to that sensor. | ||
** Actuators: I guess the big one in cells is somehow affecting the transcription or translation process. | ** Actuators: I guess the big one in cells is somehow affecting the transcription or translation process. | ||
*NWP: Thought experiments to ponder for Friday and while reading paper - | |||
**If you were engineering chemotaxis where would you apply gain to the existing system to improve performance? | |||
**Simple sounding task, How would you engineer a cell to move away from a chemoattranctant instead of towards? | |||
**How does time delay affect the stability of the feedback system and the choice of gain placement in this system? | |||
**If we made an analogy to PID controllers, are there combinations we can rule out and why? | |||
**High robustness comes with a heavy price, i.e. fragility somewhere in the system… How does biased stochasticity create dynamic instability in this system? Or put another way, how does the cell use fragility to its advantage? Fragility to robustness conversion, eh? | |||
**What are the equilibrium points for this system? Or put another way, does the system show any stable states which if the cell comes close to, it stays close? And do these equilibrium points depend on any of the system parameters? | |||
**Can anyone think of engineering systems that use this type of control? | |||
== Discussion == | == Discussion == | ||
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Revision as of 10:46, 15 November 2006
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What are the biological analogues of Sensors and Actuators?
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