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The Covaris S2 sonicator is a single tube system developed for high performance sample preparation. The S2 is most appropriate for samples less than 1,000 mg and volumes less than 10 ml. Using adaptive focused acoustic energy, The S2 utilizing a spherical acoustic transducer, and delivers controlled energy precisely and accurately to sample volumes from 25 μl to 10 ml. The main applications are shearing of DNA, RNA, and chromatin but it can also perform tissue homogenization for cell lysis and drug delivery and formulation.

Protocols for optimizing the sonication time for next generation sequencing can be found on the company's website:
The manual can be found here:
Schedule time on the Covaris

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