Biomod/2011/TUM/TNT/Project: Difference between revisions

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<tr bgcolor="#f5f5f5" font color="#CCCCCC"><td valign="top">Containing the blueprint for every function and structure of life, DNA plays an essential role in most fields of the biosciences. Because of this reason, detailed knowledge of compounds that interact with DNA is of great importance. For instance, small DNA binding molecules including intercalators and minor / major groove binders can cause changes in the geometry of double-helical DNA domains. Such changes can affect the dynamics of transcriptional regulation and the activity of nucleases. To name an example, the minor groove binder Netropsin is a potent inhibitor of bacterial DNA gyrases with a broad range of activity, including the notorious nosocomial pathogen Pseudomonas aeruginosa.<br>
<tr bgcolor="#f5f5f5" style="color: #55555"><td valign="top">Containing the blueprint for every function and structure of life, DNA plays an essential role in most fields of the biosciences. Because of this reason, detailed knowledge of compounds that interact with DNA is of great importance. For instance, small DNA binding molecules including intercalators and minor / major groove binders can cause changes in the geometry of double-helical DNA domains. Such changes can affect the dynamics of transcriptional regulation and the activity of nucleases. To name an example, the minor groove binder Netropsin is a potent inhibitor of bacterial DNA gyrases with a broad range of activity, including the notorious nosocomial pathogen Pseudomonas aeruginosa.<br>
Hence, small DNA binding molecules can represent candidate compounds with antibiotic or tumor-repressing activity.  Elucidating the microscopic structural changes caused by small molecules can thus help to select candidate molecules as well as shed light on functional mechanisms.</td><td>[[Image:DNA Netropsin.png|thumb|200x200px|right|Fig. 1: Crystal structure of the minor groove binder Netropsin bound to DNA.]]</td></tr>
Hence, small DNA binding molecules can represent candidate compounds with antibiotic or tumor-repressing activity.  Elucidating the microscopic structural changes caused by small molecules can thus help to select candidate molecules as well as shed light on functional mechanisms.</td><td>[[Image:DNA Netropsin.png|thumb|200x200px|right|Fig. 1: Crystal structure of the minor groove binder Netropsin bound to DNA.]]</td></tr>
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       TUM NanU - Home

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   <li><a href="http://openwetware.org/wiki/Biomod/2011/TUM/TNT/Home">Home</a></li>
   <li style="background-color: #cccccc"><a href="http://openwetware.org/wiki/Biomod/2011/TUM/TNT/Project"><b>Project</b></a>        
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           <a href="http://openwetware.org/wiki/Biomod/2011/TUM/TNT/Project#The_Idea">The Idea</a>|
           <a href="http://openwetware.org/wiki/Biomod/2011/TUM/TNT/Project#Project_Specification">Project Specification</a>|
           <a href="http://openwetware.org/wiki/Biomod/2011/TUM/TNT/Project#The_Structure">The Structure</a>|
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