Biomod/2011/TeamJapan/Sendai: Difference between revisions
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Revision as of 07:48, 20 October 2011
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<ul id="verticalmenu" class="glossymenu"> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai">Home</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Strategy">Strategy</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Design">Design</a></li> <li><a href="#">Experiments</a>
<ul> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Results/Electrophoresis">Electrophoresis</a> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Results/Atomic_Force_Microscope">AFM</a> </ul>
</li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Computational_design/Simulation" >Simulation</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Notes">Notes</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Team">Team</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Resources">Resources</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2011/TeamJapan/Sendai/Sitemap">Sitemap</a></li>
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Welcome to the wiki of the TeamJapan: Sendai !!
abstract
Designing a molecular robot is one of the most interesting and challenging targets in biomolecular design. This year, three teams from Japan and one from Denmark propose the first “molecular race”over a defined track made with DNA origami. We are now making a molecular robot for the race.
Our molecular robot and its mechanism for movement are based on the molecular spider developed by Lund et al. (Nature, 2010). In the original design, the spider body consisted of the streptavidin protein, and three DNA-based legs are attached to it. The walking movement of the spider is random, unless its movement is driven by a defined pathway over DNA origami. Consequently, the movement of the spider is slow and inefficient. To win the race, we want to substantially improve the robot performance. For this purpose, we make the whole structure of our robot with DNA, which allows us to design arbitrary geometry of the body and to increase the number of legs. Also, we can assign different base sequence to each leg and scaffold on the field. These new parameters give us freedom to optimize our robot design. We have been developing a stochastic dynamics simulation model in order to evaluate different types of robot, searching for the optimal design. In the final report, we will show our optimal design and the details of experimental results including its walking motion captured by a video-rate AFM. |